wwwtyro

Joined 15 years ago

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922
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296
Member since
Oct 23
website: wwwtyro.net
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Comment · 2 months ago
Also hand washing!
Comment · 9 months ago
> Bile is used to process food in the gut. It does not go back into our system.

I don't think that's correct: https://en.wikipedia.org/wiki/Enterohepatic_circulation

I also think you're mischaracterizing HDL as a VLDL. If you search for Apolipoprotein A here: https://www.ncbi.nlm.nih.gov/books/NBK305896/ you'll see that HDL is constructed from it, while VLDL and LDL are part of the Apolipoprotein B lineage.

Comment · 9 months ago
My understanding is that:

1. When someone consumes fat, bile is released into the gut.

2. Oatmeal (and other soluble fibers like psyllium husk) capture this bile and it is excreted in stool.

3. In order to create the bile, the liver needs LDL. Because the LDL it used to create the bile was lost when it was captured, it exposes more LDL receptors and pulls LDL out of the bloodstream, thereby lowering LDL levels.

It seems to me that in order to maximize the effectiveness of this LDL-lowering approach, one must not simply consume psyllium or oatmeal, but rather consume them in conjunction with fat. Not saturated fat, obviously, which raises LDL, but perhaps unsaturated or polyunsaturated fats. My expectation is that this would trigger the bile secretion required in order to actually sequester it.

Comment · 1 year ago
I'm not sure. It seems like the harder they squeeze, the less they can hold onto. Books, movies, TV shows, audiobooks, music - you can find it all online for free and acquire it pretty safely (torrents/vpn etc). I think the only thing they can really sell us is convenience - and I buy it! But if that convenience is lost to fragmentation, or lack of offline availability (e.g., books), or price, I think people will stop paying and do the more convenient thing. There's a tension there that I don't think they can ignore.
Comment · 1 year ago
Until we get robots with really good hands, something I'd love in the interim is a system that uses _me_ as the hands. When it's time to put groceries away, I don't want to have to think about how to organize everything. Just figure out which grocery items I have, what storage I have available, come up with an optimized organization solution, then tell me where to put things, one at a time. I'm cautiously optimistic this will be doable in the near term with a combination of AR and AI.
Comment · 1 year ago
I love the idea of open source hardware, but one issue I struggle with is - what happens when one or more components go out of production?

I suppose one solution is that the maintainers could update their component list (which might involve more than one component because of compatibility issues?). But what if I'm in the middle of purchasing the components only to discover I can't get them all? Maybe the maintainers could sell component kits? That might be a nice way to fund their work. Not sure if that would run into issues with IP laws, though.

Comment · 1 year ago
Comment · 1 year ago
How does anything swing -1000%?
Comment · 1 year ago
Do you mean medium of exchange? I think it's difficult to make the claim that the USD is a good store of value.

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