v8xi

Thats super interesting I've never heard of this before. It seems that toxin gives a persistent increase in the activity of the sodium channel(s) that make cold painful. I imagine similar to how cold water on frozen fingers feels burning hot.

Several years ago I went to a talk about a receptor (TRPM8) that is activated by cold and also minty flavors(!). Would be curious to know if your friends experience(d) mint as burning/uncomfortable. If not, it would suggest the pathology is linked to separate cold-sensing physiology/pathways/neurons than the common "cool" feeling most are familiar with.

Theres a guy Grant Harding on YT etc. who sends gas station pills for testing and some of the things he finds are scary. Seriously addictive drugs being sold OTC with no meaningful consumer warning or guardrails

are you not a true believer of the efficient market?

next you should explain idioms

As an adult that kind of feedback feels like a sales pitch. As a kid its unforgettable validation. Wonder when that change happened.

I introduced this to so many people as the only one who knew how to play. Key is start the game with 3 cards and win the round quickly + be super diligent about the rules so no conflicting information. Win the round quickly, add an obvious rule and by the third round it's fair play.

I used to play this a ton (often as a drinking game). The wiki does a good job of explaining the basics and I'd always do the no talking + point of order variants (+ a few others). My favorite type are:

1) rules requiring awareness of card order. "Have a nice day" is standard on 7, double 7's is "very nice" etc. Stack rules like that when combinations and/or cards of a suit are played and people have to remember 5 things they have to say or do after a card. Get's difficult over many rounds.

2) ice-breaking rules (if you're playing with new people). Friendly ones like "you must compliment _ when a _ is played." Great way to build/open someone up

3) rules changing play order. Aces reverse, add rules that e.g. skip a player and you'll have everyone waiting in suspense to see if the person who's turn it is actually knows its their turn. If not, "delay of game".

Play it with friends you'll be surprised with what people come up with!

Just remains to be seen whether they can maintain capitalization long enough to find PMF

i just picked up an ultimaker s5 for $400 on ebay with tons of extra filament and it worked off the bat. Been printing for almost 2 weeks straight and my daughter loves it :D

Christmas 1999 my father's business had just gone under when the banks stopped lending after the dot com bubble. We didn't have any presents until Christmas morning when our church dropped off a bunch of presents for us. We got a Razor scooter and I spent all day riding it downstairs. I just got my daughter a scooter and she's doing the same this year :)

Was going to say about the same - this is ~2500 years after construction of the pyramids. How do you coordinate something that massive without any form of writing?

In graduate school we had to answer this on a test question and it took all of 5 minutes...should have published it, I guess