tuna-piano

Joined 12 years ago

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Comment · 1 year ago
Thanks for the healthy skepticism.

I still think there's a lot to learn from those articles for most folks uninvolved in this area, even if some of their immediate optimism has additional complications.

I think what I mostly took away is a combination of technologies is likely to dramatically change how we have babies in the future.

1. We'll make sperm/egg from skin cells. This has already been done in mice[1], so it is not science fiction to do it in people.

2. When we're able to do this inexpensively, we could create virtually unlimited embryos. We can then select the embryos that have the most optimal traits. Initially, this may be simple things like not choosing embryos with certain genes that give higher risk of certain diseases.

This may involve selecting traits like intelligence and height (there are already companies that offer this embryo selection capability [2]).

3. Instead of creating a lot of embryos and selecting the best ones, we could instead create just one embryo and edit the DNA of that embryo, which has already been done in humans [3]. Alternatively, we could edit the DNA of the sperm/egg prior to creating the embryo.

The fact that none of this is science fiction is just wild. All of these steps have already been done in animals or people. Buckle up, the future is going to be wild.

[1] https://www.npr.org/sections/health-shots/2023/05/27/1177191...

[2] https://www.theguardian.com/science/2024/oct/18/us-startup-c...

[3] https://www.science.org/content/article/chinese-scientist-wh...

Comment · 1 year ago
Comment · 1 year ago
What's funny is the tariffs announced a couple day sago explicitly excluded semi conductors and pharmaceuticals. We are literally about to tariff t-shirts but not those more strategic industries.
Comment · 1 year ago
Spending Buffet's staggering fortune in a manner nearing anything efficient feels like a herculean task that even the most capable would struggle with.

Objectively, his kids have not demonstrated any capability to do something of this magnitude. It's really quite disappointing to see Warren mostly backtrack on what he's always said (around nepotism and leaving staggering sums to future generations among other things).

You'd think even if this is related to Gate's Epstein connection, he would still recognized the importance of using his net worth for maximum good.

Maybe the human instinct to leave your possessions to your children is too strong for even Warren to fight.

It's really quite depressing watching the fiasco of how Mackenzie Bezos is donating her fortunes and what seems likely to come from Buffet's children. So many resources created+collected by brilliant people and then squandered by their loved ones.

Comment · 1 year ago
Without a doubt "Endurance: Shackleton's Incredible Voyage" by Alfred Lansing.

Read it, read it now.

It's the kind of book that you once you read, you'll never forget. 4.8 stars with 23k reviews on Amazon. Similar survival story vibes as books like "Into Thin Air" or "Into the Wild" but just on another level. It follows the story of a journey to Antarctica in 1914 that goes wrong and ends up with the ship trapped in ice for many months, and follows the crews absolutely insane attempts at survival.

I am waiting for time to forget enough of it so that I can read it again.

Comment · 4 years ago
Comment · 4 years ago
Comment · 4 years ago
No 17 year old college applicant has power.

What would you call treating a 17 year old different based on their skin color? If we can't use the word racism anymore, then I'll call it bigoted.

Comment · 5 years ago
I'd love to see a 2019-2021 salary change by height study. Or Zoom interview vs in person interview acceptance rate by height. Did short people benefit more compared to tall people given the remote work+hiring situation?
Comment · 5 years ago
Amazon claims cameras automatically track what you take and put back. But if that's the case, then I'm left confused as to why receipts take so long (15-20 mins+ sometimes) to be generated after leaving the stores?

Is it possible it's actually a manual process of people watching the videos, or more likely identifying what happened at each "take off shelf/put on shelf" point?

They're still just building up the customer base, training data and models and it's not as magical as it all seems?

Comment · 5 years ago
Comment · 5 years ago

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