trevorkoob

One interesting aspect of Vitamin D that is not regularly discussed is the photo-isomerization of Vitamin D into inactive isomers in the skin.

I think of it similarly to Beta-Carotene, in that consuming the "natural source" has no known toxic amount, while consuming processed vitamin A can be toxic in large doses.

Increasing sun exposure will not raise blood vitamin D metabolite concentration indefinitely, and we don't have good studies that accurately measure the amounts of Vitamin D and its photo-isomers and their concentration in relation to large doses of UV exposure.

Therefore, through sun exposure, people may be storing large doses of Vitamin D isomers in their skin, keeping their levels much higher than typically prescribed oral supplementation levels.

When I did my master's thesis on Vitamin D supplementation the conclusion was that vitamin D testing is wildly inaccurate, and we needed to have studies based on a target level - ideally one based around sub-saharan African community levels.

As for supplementation, sunlight has been estimated at providing up to 20,000IU per day, which I think (not medical advice due to the lack of study), from a mechanistic point of view, suggests an upper limit to daily supplementation.

You may have a point about processing, but I think by talking about "most people" you have invalidated any future points you may be trying to make.

For example:

"single natural ingredient"

not every cow is only fed with grass, and what about that grass, has it been treated, etc...

also

Neu5Gc

Mammal meat contains it, Humans have lost the enzyme (perhaps over that time since "the dawn of man"), it causes inflammation.

Looking at chimpanzee diets, I don't think our common ancestor was regularly eating burgers. More likely insects and leaves...which do not contain Neu5Gc.

As a self-proclaimed "healthy person", I'm not regularly eating either of these, but unless I know where the meat comes from, I'm likely sticking to the non-inflammatory burger.

I've stopped using photos entirely due to import bugs.

So much wasted time, now I just use image capture to import and organize directly.

Still get errors from time to time.

Apple needs to hire more quality control, their software integration is going from a positive to a negative.

Seamless integration was a large part of Apple's initial hook, and continues to be a part of their drive to push services, it should be a priority.

The hypothesis was: is it beneficial to supplement vitamin D to reach the maximum levels achieved through sun exposure year-round?

Conclusion: these types of studies did not exist at the time, but the risks of doing such studies would be minimal, and such studies would be able to test for the effects of higher dose supplementation that were lacking at the time. Potential benefits include increased muscular strength and bone strength.

Thank you for replying!

Curious.

Could you please share your physical activity level around the time of supplementation?

One of the most interesting studies I found in my research of vitamin D was a study in an elder care center where the patients were given massive doses of vitamin D.

The result of the massive doses were that patience had less hip fractures, but more falls compared to the control.

Now take this next part with a grain of salt because it’s me extrapolating from this result, but due to the known effects of vitamin D on muscle strength and also on bone density, I imagine that these patients were more active, but because vitamin D doesn’t give you coordination as well as strength they were falling more, their bones were more dense so they had less fractures per fall.

The point I’m trying to make and the reason I am curious about your own activity level, is that perhaps that there is a sensation or feeling of your muscles being more primed for action which can be agitating. Perhaps regular activity can link one’s sense of proprioception with increased muscular ability.

Apologies in advance if this is too personal of a pry.

Other than the value you are aiming for (I personally aim for the upper edge of the normal range), I agree with the immense variability in dosage, and also would like to mention imprecision in vitamin D bloodwork tests as well.

Thankfully throughout my Vitamin D research, I found low risk of overdose, and cases of immense accidental overdose that appear to have been treated successfully (mainly by stopping the over-intake).

Adding on this point, in my research I found blood serum testing to be wildly imprecise.

The conclusion of my study was that we should do more studies where we take regular blood level samples and adjust dosage to achieve a certain average level (near the upper level of the range).

5000IU D3 (D2 is about 1/3-1/2 as effective at raising blood serum levels) is a good starting point.

Did a masters on Vit D.

Multiple overdoses of over 1 million IU have been recovered from without obvious long-term damage present in near term follow up.

Out of vitamin D’s many potentially clinically positive effects some of the clearest and best evidence is for increased muscle strength.

Personally I take between 5000-10000 IU D3 daily depending on exposure to sun intensity.

testing lying down as we speak. Much more comfortable. The killer market for this device is business airline travel.

15 minutes of full-body UV exposure from the sun is estimated to provide the equivalent of 20-30,000 IU Vitamin D3.

There is a definite need for studies that better determine the effective dose for D3.

My research led me to the conclusion that studies should be done based not on standardized supplementation, but instead supplementation to a standardized blood serum level.

Makes sense that we have been cooking for a long time.

Our intestines look as though they have evolved around an environment of cooked food, and that takes many many thousands of years

Distributed ledgers are not a scam, and our true best hope for anti-corruption.

I would like every elected official to have all their income and spending listed on a public ledger.

True accountability of representatives to those they purport to represent will solve so many problems, both in terms of the types of people incentivized to become public servants, and also in terms of public understanding of spending and waste.

All this "crypto" is intellectual warm-up for what is to come, I'd highly suggest looking at rollups (what I would describe as ledgers within ledgers) which are delving into the true possibilities of next-to-zero cost of immutable transaction records.

Chiming in to thank you. The access to quality information on the web, specifically Ebooks, is what gives me hope for the future.