roadnottaken
Joined 16 years ago
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2,987
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508
Member since
Jun 19
Recent submissions
Comment · 5 months ago
No, the KRAS mutations are somatic (spontaneous), not inherited
Comment · 4 years ago
Seconded
Comment · 5 years ago
This has been going on for decades, it's called GWAS [1] and it has had a few successes but basically hasn't worked as well as everyone hoped it would in the 90s. The reason it doesn't work that well is that the human genome has ~3 billion letters and human physiology is complex. So trying to establish stastitically significant correlations between genome variations and human physiology is hard and requires more than Excel. In fact, the computational tools that have been applied to this are incredibly sophisticated and are not the limiting factor. The limiting factor is that you probably need millions or billions of genomes to make it work, and we don't have that yet. Also people are beginning to realize that many disease-relevant traits are caused by rare variants (rather than obvious statistically significant correlations) which are quite hard to detect this way.
So... anyway you're right that this is a natural way to approach the question of understanding the genetic basis of disease and physiology. But it's been beaten to death and found to drive fewer insights than were hoped
[1] https://en.wikipedia.org/wiki/Genome-wide_association_study
Comment · 5 years ago
biotech != computing
There are some important differences that are often overlooked by those coming from the world of computing...
Comment · 5 years ago
I wonder if they just killed the affected service so it's loading faster-than-usual now
Comment · 7 years ago
And? do those editors have a history of allowing or blocking untruthful ads?
Comment · 7 years ago
Why hasn't this issue come-up with print advertisements? Seems like it should've been addressed eons ago...
Comment · 7 years ago
It's been a ~10 year bull market. 1999-2009 was basically flat.
Comment · 7 years ago
Yeah, but it matters when you’re in healthcare
Comment · 8 years ago
I think this case blew-up because the Saudi's were caught red-handed. Erdowan realized he could put extreme pressure on the Saudi's because his evidence was so strong. I think you're probably right that this sort of thing happens with some frequency, but you can only call foul if you have hard evidence which is much more rare.
Comment · 8 years ago
tabview [1] is a somewhat simpler tool for navigating tabular data that I install everywhere
Comment · 8 years ago
How could they not-even mention which gene is mutated? I'm a biologist and it was the only piece of info I wanted. The video even asks if you know anyone with this gene mutation, but doesn't say what the mutation is.