porridgeraisin
Joined 3 years ago
Joined 3 years ago
/genuine do you recommend any other blog?
Hmm.. I think it's my terminology issue. I just meant pocket as in informal word for "subspace", that is, generators can learn to generate good candidates within some subspace without needing to be good classifiers across the whole space.
But yeah as a whole that makes sense, thanks.
> unless you can create a magical classifier
A generator could concentrate on pockets while remaining unable to judge most drugs. And LLM RLVR a) works well, and b) is black box optimisation and so is suited since it doesn't need system identification (which you can't do for complex biological systems). So the hypothesis is that, yes making a classifier is very very hard, but you could through some (lots?) initial interactive data, end up with our generator outputting with high probability drugs-that-end-up-passing-trials-with-probability-p. Whether these drugs thus generated are drugs we care about (i.e, whether `p` is good enough) and whether the whole pocket it generates in is large enough, and how jagged this behaviour is (i.e distribution of `p` across taxonomies of drugs), are the few questions we want answered.
Currently academia