patrickkidger

I'd love to have a way to make xlsx files be git-compatible, i.e. stored in plaintext.

I realise this may be out-of-scope as it's kind of baked into the file format, but does Nobie offer any functionality in that direction?

I'll offer a +1 to the sibling comment here.

Yeah it's totally true you can't build a one-size-fits-all foundation model, the data just isn't there. But also... no-one needs that. It's totally fine to tweak a foundation model for any individual problem, and that's the bulk of what is being described in the linked blog post / in the underlying paper.

FWIW whilst at Cradle we had a lot of doubts going into this. Like, thermostability is clearly evolutionarily correlated so it was always pretty likely that by hook or by crook the models could do that correctly. But, binding? Aggregation? Not at all clear that the same principles should hold. And the exciting finding was that yes, yes they do.

Oh hello Thomas, fancy seeing you here :D ex-Cradlers unite!

Oh heck, this is awesome to see on the front page! I wrote the underlying Cradle-1 paper that is being discussed!

I used to work for Cradle and writing this paper was the last thing I did before leaving – on good terms – to found my own startup. :D And we'll 100% be using Cradle for our lead optimization.

(On the off-chance: I'm at PEGS Boston this week chatting all things AI+antibodies, in particular for rare diseases. If this topic is of interest to any other protein+tech geeks here then send me an email, let's grab coffee.)

I'm not sure if I'm about to be the old man yelling at clouds, but Anthropic seem to be 'AWS-ifying'. An increasing suite of products which (at least to me) seem to undifferentiated amongst themselves, and all drawn from the same roulette wheel of words.

We've got Claude Managed Agents, Claude Agent SDK, Claude API, Claude Code, Claude Platform, Claude Cowork, Claude Enterprise, and plain old 'Claude'. And honourable mention to Claude Haiku/Sonnet/Opus 4.{whatever} as yet another thing with the same prefix. I feel like it's about once a week I see a new announcement here on HN about some new agentic Claude whatever-it-is.

I have pretty much retreated in the face of this to 'just the API + `pi` + Claude Opus 4.{most recent minor release}', as a surface area I can understand.

It also applies to any .py file. (At least in practice with e.g. pyright)

That said, the documentation on this matter is close to nonexistent.

Yup, you(/sibling comments) have it correct, it's to mark it as private.

Not sure where I got it from, it just seems clean. I don't think I see this super frequently in the ecosystem at large, although anything I've had a hand in will tend to use this style!

Oh neat! This is my library. Happy to answer any questions.

(Though it's really a pretty tiny library that just does what it says on the tin, not sure how many questions there can be. :D )

Went scrolling looking for this! Most of the article is about problems solved in JAX.

Also worth noting the Array API standard exists now. This is generally also trying to straighten out the sharp edges.