pak

Joined 16 years ago

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827
Member since
Mar 29
Assistant Professor at University of California, Irvine

Opinions posted here are my strictly my own, and not representative of any employer or organization that I am a part of.

https://tedpak.com

[ my public key: https://keybase.io/powerpak; my proof: https://keybase.io/powerpak/sigs/fEW8iI_3tD3E9XjbSaPJTDOtaai7TXU6j1QAezE82Xc ]

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Recent submissions

Comment · 2 months ago
OpenSSH has the best track record, but even it had a zero-day RCE (regreSSHion) in 2024.

There are bound to be many more discovered as LLMs capable of doing so proliferate among those who don't report such things responsibly.

Keeping port 22 open puts you first in line for such exploits, while keeping it behind another layer (whether it's WireGuard or firewall tricks) would buy time, if not keep attackers away entirely. That seems useful, no?

Comment · 3 years ago
Comment · 3 years ago
You know we’re doomed when half the comments here are taking this seriously, and not as the satire it clearly is (1KB of state? come on people)

Props to the OP for showing once again how lightheaded everybody gets while gently inhaling the GPT fumes…

Comment · 4 years ago
Comment · 5 years ago
People already do need it! In the US alone, about a half million people are on dialysis. There are many health and functional consequences to both intermittent and peritoneal dialysis; they are not exactly benign treatments.
Comment · 5 years ago
The major benefit to implanting it under the skin, as we do with pacemakers, is that doing without permanent holes or tubes through the skin reduces infection risk.

Consider also the danger of having something dangling from your body that is powered by your arterial blood pressure (from a major artery, as the kidney is). A trip and fall could be instantly fatal.

Comment · 5 years ago
Comment · 7 years ago
The video evidence of the L-form switching is no doubt very interesting, but a more accurate headline would be “One cause of resistance to certain antibiotics in UTIs identified.” Or the original article’s title, which is “Possible role of L-form switching in recurrent urinary tract infection”; see https://www.nature.com/articles/s41467-019-12359-3

I would love to see data on how common this phenomenon is in various populations of UTI patients (elderly, young, inpatient, outpatient, etc), given different prior exposures to antibiotics; for now it looks like 30 patients were assessed.

There are obviously many different causes of resistance previously identified, going all the way back to penicillinase enzymes inactivating penicillin. As often happens with lay summaries, this makes it sound a little too much like the cause of all antibiotic resistance has been found.

Comment · 9 years ago
Well, for starters, it's hard to get 200 people who might be eligible for life-preserving surgery to volunteer to possibly get a sham procedure for the exclusive benefit of othewars; not to mention build a team of surgeons, hospitals, etc. willing to do the trial; and someone to pay for millions of dollars in treatment and administrative costs. Clinical trials involving surgery, especially with sham procedures as a proper control, are exceedingly rare in the US for these reasons. (this is discussed in the OP itself.)
Comment · 9 years ago
Comment · 9 years ago
Comment · 9 years ago
Thanks for replying! I'll certainly be looking forward to the publication.

>about 10% of people who come in to the cardiology clinic experiencing symptoms are diagnosed with an abnormal heart rhythm

OK, but I'd be more careful about staying apples to apples in your comparisons; your app is about asymptomatic AFib. So how many of those people going to the cardiology clinic had undiagnosed AFib; for how many of those would a new diagnosis of AFib have changed the plan of care; etc. Kind of like robbiep was saying, I would be interested in actual added value from the larger perspective.

Totally appreciate your point about perfect being the enemy of the good. The danger is that these semi-medical wearables currently straddle a strange zone between medical and consumer use. The inevitable marketing strategy is to co-opt the positive reputation of medical products while acknowledging none of the pitfalls of consumer products. Most of the screening methods you bring up are used by a doctor on symptomatic patients with a suggestive history, and only as a partial component of clinical judgement. The way Cardiogram seems to make the most money, on the other hand, is to sell the product to asymptomatic, casual users. (Furthermore, CHA2DS2-Vasc costs 30 seconds of talking or reading a medical record, not $700 in Apple products.) So you're inevitably running up against some doubts among physicians [0].

And finally, I agree that more machine learning practitioners should join medical research. I hope the field works to set more reasonable expectations, however, as in: ML will solve very specific subtasks in clinical reasoning (as in the diabetic retinopathy study [1]). Instead, the headlines usually ratchet that up to "AI will replace radiology/cardiology/$specialty in X years." That tends to hurt the people currently in the trenches, since their contribution in bringing about practical, incremental change is diminished. The top answer of this Quora thread [2] has a good discussion of the many dimensions of the problem.

[0]: https://twitter.com/Abraham_Jacob/status/860119573915287552

[1]: http://jamanetwork.com/journals/jama/fullarticle/2588763

[2]: https://www.quora.com/Why-is-machine-learning-not-more-widel...

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