mfld

Never trust a statistic you haven't sneaked into the training corpus yourself.

My hunch is that improving those proofs specifically might be a similar endeavour as improving a large vibe coded app.

Great idea! During my time as a researcher, I heavily used org-babel. I used it to put code for data wrangling, plots, and notes into a single document. The notes would often contain formulas to describe what was done. I would regularly export that to PDF using pdflatex to send it to collaborators. Maybe this is an avenue worth considering for Ledge.

> For now, this is mostly a story about how AI can be used to parse existing data to discover new biology (which is fantastic!).

I'd like to expand that: in my view, this is also a story of how agentic AI systems can come up with bioinformatics strategies to discover novel features. One would think such a task would be the ideal domain of the genome language models, which have learned the structure and functional relationships of DNA/RNA sequences. The agents instead relied on classical bioinformatics methods such as HMMs to make their discovery.

Note: I could not find the Supplementary Note 1 that was supposed to describe how exactly agents came to their solution, but I assume it was autonomous.

What would be a typical size of the search index, let's say after 5 years of intense browsing?

Remember when Google acquired YouTube for $1.6B in 2006? That amount seemed ridiculous at the time. Its now peanuts compared to YouTube's yearly revenue.

Very interesting project! I can imagine usefulness even beyond the intended use case, namely in joining the information from multiple large genomics studies. The sharing and access of such data becomes increasingly difficult, and by this approach one could increase the effective sample size while keeping the data private.

YSeq, TellMeGen - or reaching out to local sequencing labs

Very cool! Looking forward to try out the xref and markdown features. The latter becomes increasingly important since the developer community at large seems to disagree with org-mode being the superior syntax...

Maybe for marketplace articles shipped from outside the EU. It's not legal, so Amazon will surely have a close look (for directly sold items), as well as any company shipping from within the EU.