mdevere

This is very, very weak.

Clinical science is inundated with well-reasoned "potential leads". Ideas for targets, and even designing drugs to interact with those targets in the desired way, is not the bottleneck. Hasn't been for decades. The bottleneck is in clinical development i.e. human trials.

There are many many AI drug discovery companies out there, many of them very well funded, and ALL of them with no shortage of "potential leads".

These companies usually start out with the idea that their potential leads are better than the alternatives (generally because they cast a much bigger net/ considered more screening criteria than a human could, thanks to AI) and that big pharma will pay them license fees.

And yet, all of those companies, pretty much without exception, have turned into drug development companies themselves. They are forced to develop their own "potential leads" into actual approved drugs. And they are subject to the same timelines, same costs and - so far - the same probabilities of success as any other drug developer.

PerturbAI & OpenAI's "potential leads" might be better or worse than the next AI company. I would guess worse, given there is zero proprietary data involved and no clarity about why the underlying models are going to generate insightful findings. Either way, not useful.

PHOTOS

Glad to see that Shared Albums are now full resolution!

Now, please:

1. Allow us to edit the photo order of the Shared Album (instead of the order that the photos were added to it). Currently, my wedding unfolds in the wrong order, and my kid turns 6 months old before being born.

2. Fix identification/clean-up of duplicates.

3. Give us a way to tidy up facial recognition.

4. Allow us to join "best quality possible" collectives, which will replace our poor-quality photos with higher-quality originals from somebody else's library.

If this is true, I'll need to stop using Backblaze. I have been relying on them for years. If I had discovered this mid-restore, I think I would have lost my mind.

Very strange how HN elevates news about random drug candidates at very early stages of development.

There is a very active landscape of people developing/validating 'biomarkers' for neurological and psychiatric disorders and developing drugs specifically for those populations with the biomarker present; this news is far from extraordinary.

The real news is when these reach FDA approval.

Big fan of Bitwarden, albeit you are putting a single point of failure on all of your secure info.

I'd love to know what others do to maximise both convenience and security.

For two-factor authentication, I wouldn't use the same service for both layers. Seems daft to use Bitwarden as both the password keeper and the TOTP provider. Not sure if that's a cryptographically coherent view, but hey.

Every day I have to use something like 4gb of data to let Backblaze sync. This is despite the fact that I might only have created/changed 100mb worth of files since the previous day's sync.

He is out of his mind

How can you be the real Satoshi when _I_ am the real Satoshi? This guy is a fraud, don't listen to him!

Can someone explain to me how open source products can generate revenues like this?

Only 16m more to go

I don't have pics anywhere. That's all in Photos app/ iCloud. It's very cheap, something like $1 per month.

I use Backblaze to backup everything to cloud.

This is not a problem