in9
Joined 9 years ago
Joined 9 years ago
### They did not do a non-vaccinated vs vaccinated people comparison
These studies are observational, and in that sense no manipulation (such as random treatment assignment) was made. So they need to rely on observational studies techniques.
From what I could gather, one of this observational techniques in inverse treatment probability weighting when they say
> "we adjusted for all baseline covariates using stabilized inverse probability of treatment weights"
The IPW technique basically tries to solve the problem that some groups of children might have a higher prevalence of the treatment by weighting them in a manner as to mimic random assignment. This is as close as we can get to comparing treated and untreated in observational settings.
Also, the division of the doses of vaccine is also a better characterization of "was vaccinated". If you think getting vaccinated causes something, then getting more vaccinated should increase the incidence of that something.
### Wouldn’t you need a sizable cohort of non vaccinated children?
Yes, but as you pointed out, that might not exist. So by creating comparable groups (via IPW) + treatment intensity/dose we can still arrive at some conclusions.
### The researchers discarded from their cohort 34,547 children for receiving too many vaccinations/too much aluminum (...) Wouldn’t that data be relevant to look at?
They probably did. A few things are important here. The data comes from administrative data sources, so mistakes can happen. While you need to trust the sources, there could be imputation typos, or just weird cases. So the researchers probably went after a notion of "clinically relevant vaccine dosage for this study" to know up to which point to consider data points, because from that point onward, it either is not interesting because its a rare treatment incidence, or just seems like a mistake.
### “adjusted hazard ratio (95% CI) per 1mg increase in aluminum received……” and in the chart Asperger’s is listed at 1.13 (.89 - 1.44) so they do potentially see an increase for Asperger’s
Important to say that with hazard ratios, a HR of 1 means that there is no change because we are in the multiplicative scale (as opposed to 0 meaning "treatment does nothing" in the additive scale).
So in this setting, after adjusting for the treatment probabilities, a HR CI of (.89 - 1.44) just translates to 'no effect'. Nothing out of the ordinary in terms of the interpretation.
- Structure and Interpretation of Computer Programs: this helped me understand the different types of recursion; how a problem can be modeled for the code to solve and how those designs can evolve and how the paradigm I'm using (functional or OOP) can help me
- Refactoring: this book helped me understand the different patterns we can use to alter code. Giving them a name and symptoms is a great way to apply and communicate with other coders. I recommend this book to everyone.
- The little Lisper: this really helped me get recursion. Like really. Although I could use a refresher.
- Clean code: look... this book is bad. Like, really bad. But, at the time I read it, and in the languages I used (Python, C, R) we didn't have many rules on how to write and organize our programs. And I wanted to improve on that skill. And this book gave me pointers and made me think about those ideas. I don't recommend it around, because for many people Clean Code can become a dogma really easily. But if you can question and critique and reach out to other resources and is an advanced beginner to coding, I can see this book bringing value.
- An Elegant Puzzle and Staff Engineer by Will Larson: those helped me get clarity on the role of the technical team in an organization. A team that produces code as the main driver of impact in a product/service. I lump them both because I read them back to back and don't remember, exactly, which is which. But une is more focus on a tech leader and the other a tech specialist.
- Unix and Linux System Administration Handbook: whenever I need to interact with some unix technology, this book delivers in terms of giving me a nice historical view and presenting the common tooling around the tool. This helps me interact with stuff programmatically much better. Be it GRUB, X, SAMBA, this book gave me the necessary introduction I needed, much more organized and thought out and with useful references than the average blog post you will find in the wild.
And I'd like to recommend this Ask HN on problem solving books
This is a view that, depending on the lecturer, can be the total opposite of their view. See, many mathematicians don't have this instrumentalist view on math and some even despise it with their heart. They don't care about applications and don't get particularly excited when a problem was solved in another domain with their technique.
Also, solving a particular problem is that, a particularity. They look for generalizations and for rules and methods that can be applied regardless of the domain. That is why weird and contrived examples are the bulk of their logic, since when you look for generalizations, those are the cases where it breaks. Does continuity implies differentiability? For almost all practical cases yes, but when you want to be general, thats when you get the Weierstrass function [1], a weird function that needs to be studied if you want to develop a theory of real valued continuous functions. Yet, such knowledge is extremely impractical for you average engineer or deep learning researcher.
And ok, you might argue that "I'm not at such level, I don't need those particular theoretically interesting cases since I'm not going to study advanced mathematics at that level". Ok fine, I respect that. But that is not part of the "culture" of mathematics (a culture which your lecturer likely comes from). Since the subject is learned and investigated with this "quest for generality which makes us study weird examples" this is how it is passed along, and this is how it is studied and structured.
All that to conclude: I think its best to respect how math is structured. First, it is precisely the type of thought that I think very other applied fields lack, but that actually helps solving problems. It is by seeking generality, and looking at corner cases that stuff gets built. And mathematicians are the best at formalizing those because this is how they advance their craft. Second, and last, its by creating your own investigation and development of examples that you can stride for a more applied and practical version of the course. That way you'll get the most out of the course.
The book I'm reading, Taking Charge of Adult ADHD, mentions that for an evaluation and diagnosis to be reliable in adulthood, the current form of symptoms should be happening for the past 6 months.
great book btw, highly recommend it.