Recent submissions

Comment · 8 years ago
But first one must be able to connect with people... since I can’t do that, the rest is considered behaviors of an pointless, unrespectable, unworthy fool, while everyone else is mostly “take, take, take.”
Comment · 8 years ago

    #ifndef SUCCESSFUL_H_
    #define SUCCESSFUL_H_ 1
    #ifdef __cplusplus
    extern "C" {
    #endif
    int will_code_for_awesome_benefits(void);
    #ifdef __cplusplus
    }
    #endif
    #endif /* SUCCESSFUL_H_ */
I guess the OP implies there’s a difference between a contractor making say, $45k USD/yr, with an unsteady existence of temporary work and an SA/SWE-SRE/TPM/SRM at Alphabet making $325k/yr in a fairly-cushy, mostly certain job with full-time benefits.
Comment · 8 years ago
No, read the source article.

The validation data are taken at baseline from three previously published studies investigating pharmaceutical interventions to normalize metabolic abnormalities of children with ASD31: (1) a combination of methylcobalamin and low dose folinic acid32, 33 (2) high dose folinic acid,34 and (3) sapropternin.35 Given that these studies all focused on evaluating treatment strategies for ASD, all participants had a confirmed diagnosis of ASD. FOCM/TS metabolites were available for 154 (76% male) participants with ASD with a mean age of 8.8 years (range 2–17 years). These ages are different than reported by Delhey et al.34 because this study only required that measurements be available at baseline, rather than both at baseline as well as the conclusion of the treatment phase. Furthermore, stratifying patients by age or gender did not reveal any differences in the univariate metabolite distributions. The first two studies were approved by the IRB at the University of Arkansas for Medical Sciences and the third study was approved by the IRB at the University of Texas Health Science Center at Houston. All parents gave written, signed consent and patients provided assent when appropriate.

2.3 Metabolites

The metabolites under investigation are presented in Table 1 and additional details of these measurements and derivations are presented in Melnyk, et al.30 This is only a subset of the measurements investigated previously29 because “% DNA methylation” and “8‐OHG” were absent from the validation data set and were therefore removed from this study to ensure that a consistent set of metabolites are used for training and testing.

(Table 1 - 22 metabolic variables considered)

https://onlinelibrary.wiley.com/doi/full/10.1002/btm2.10095

I’m curious if these metabolic abnormalities apply to adults as well. I had an ADOS at the UCD MIND Institute come back with a 7 (1-14 scale IIRC) about 10 years ago.

PS: PKU treatment sapropterin (Kuvan) costs $100k USD/yr

Comment · 8 years ago
Ever since the JDK 1.0 days, I didn’t get why there was this C/C++ carry-over inconsistency of manually-boxed types and non-Objects primitive types separated from Objects. A type hierarchy, patterned similar to Ruby’s as an example, makes the most sense:

- Object contains a Class that it derrives from (no BaseObject or Modules)

- Class is an Object

- String is an Object

- Boolean is a two-value singleton of true and false

- Number is an abstract subclass of Object

- Decimal and Integer are abstract subclasses of Number

- Float, Double, LongDouble, BigDecimal are concrete subclasses of Decimal

- SignedByte, Byte, Short, UnsignedShort, Int, Unsigned, Long, UnsignedLong, Char, BigInt are concrete subclasses of Integer (or U/I/F## types reminiscent of Rust instead of C type names)

and so on.

Then there is no boxing/unboxing of simple types or literals because they are one-and-the-same, and no there’s no confusion about how to interact with any truly generic type of value.

Comment · 8 years ago
Comment · 8 years ago
It’s absurd how much goes into the bin. Why can’t restaurants especially use cloth napkins that are cleaned off-site and also silverware, plates and cups like what was done for centuries? Getting all restaurants’ service paraphernalia away from disposable-like-Ikea-furniture to nearly zero waste seems entirely doableb because that’s how it was before. Even store beverage containers like seltzer water are refilled without melting them down, why can’t more manufacturers go back to the deposit system and just clean containers instead of completely destroying and remaking them for every use?
Comment · 8 years ago
Stanford / Palo Alto gave up on a lot of recycling and went to “off-site sorting.” Stanford used to have 5! bins.

Another fail is “recycling” at Costco, where basically no recycling happens and people just throw things in carelessly into any of the 3 bins. Worse, the staff contribute to its demise equally by eliminating the sorting signs and turning bins around to hide their labeling. Red, green, blue ... go figure which is which.

Comment · 8 years ago
Comment · 8 years ago
Corruption: It’s What’s For Dinner™
Comment · 8 years ago
CB is a YC alum.
Comment · 8 years ago
Yeah, it seems like more and more people are delaying kids until it’s “now or never” scenario. Not good. Have kids as early as possible because of the work and energy involved.

It’s not just fertility that declines, but IQ and a rise in birth defects.

Comment · 8 years ago
US immigration detention centers are now listed as concentration camps. It’s also interesting a number of them privately-owned (ie GEO Group, etc.) and also that many businesses, per article, enable their existence for blood money.

It’s the opposite of virtue-signaling if you live and work for what’s right, not out of what’s most expedient or wins popularity points, but out of integrity. Too few people these days have the courage to think deeply and act consistently regarding the big issues impact of their choices of consumption, associations and work income. (Focusing too much on tiny issues would exclude everyone.)

Comment · 8 years ago
Except for case, bolt already is a puppet project. Not a huge deal since both projects are widely-spaced.

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