Recent submissions

Comment · 1 year ago
Do it!

Want to buy some pens?

Comment · 1 year ago
Biggest smile I've had all day...

Thank you!

Comment · 6 years ago
Comment · 6 years ago
Comment · 6 years ago
Sana Biotechnology | Engineered cells as medicines | sana.com | San Francisco, Seattle, Cambridge | Full-time | Computational Engineer

We believe we are entering a new era of medicine. The ability to modify genes and use cells as medicines provides new tools to meaningfully change the outcome of many human diseases. Three aspirations drive Sana: repair and control genes in any cell; replace any cell in the body; and tear down barriers to accessing out therapies.

The Computational Engineering team has several openings for engineers to help us build out our production infrastructure. Paraphrasing Russ Cox's definition of software engineering (https://research.swtch.com/vgo-eng), our team is what happens to computational biology, cloud infrastructure, and lab automation when you add time and other teams. Beyond being a polyglot coder (Python, R, Nextflow, Terraform), we're looking for people who can have productive discussions about version control strategies, test frameworks, deployment strategies, and documentation tools and then get behind the team's decisions and move things forward.

You can find info about the openings here:

* Computational Engineer: https://sana.com/join-us/jobs/4828253002/

* Computational Engineer, LIMS: https://sana.com/join-us/jobs/4828249002/

If you've made it this far but neither of those are the right fit, you might be interested in:

* Senior Scientist, Computational Biology: https://sana.com/join-us/jobs/4589575002/

* Senior Scientist, Statistics: https://sana.com/join-us/jobs/4828246002/

Learn more and apply at https://sana.com/join-us/.

Comment · 6 years ago
> I've found it to be incredibly reliable and low overhead.

(I'm a bit confused which of tinc and zerotier in the parent post you're referring to....)

By "it", you mean tinc, correct?

Comment · 6 years ago
> Databases are made to execute queries, not to install them.

But being able to freely/quicly stand up database servers and quickly create/drop databases makes development and testing much simpler and more reliable.

Given the question: "How do you know that deploying this thing will work?"

- When it's quick/legal to stand up fresh servers and create databases, the answer can be "I tested it, just now, and it works." - Otherwise you end up in "I read through it and it looks good" or perhaps "We tried most of it on the test instance last week before the other team started using it."

I much prefer the former.

Comment · 6 years ago
[Spack](https://spack.io) uses patchelf and additional tooling to relocate it's binary packages to other paths. It generally works, although one has to special case things that burn their install directory into their builds (e.g. Perl).
Comment · 6 years ago
> But most importantly, all builds are completely reproducible.

This is only true if the commands that the recipe executes are reproducible. If someone's pulling packages from PyPi or C[PR]AN or ... w/out locking the versions, all bets are off.

This is one of my biggest beefs with many containerization sales pitches...

Comment · 6 years ago
gitlab-ci requires GitLab, doesn't it?

This doesn't, so it's an option for other settings.

Comment · 6 years ago
+1 for pinboard!
Comment · 6 years ago
Along side all of the more serious bits of the story and comments....

I love the fact that the monkey is subtly giving the photographer the finger....

Comment · 6 years ago
This is a collection of math and programming resources collected by some education-centric folks who have done several year-abroad trips over the years with their kids.
Comment · 6 years ago

Live from the official Hacker News API

A modern reader for Hacker News · SvelteKit + Skeleton