georgewsinger

I'm surprised the author didn't mention the other argument for paraxanthine being less addictive than caffeine: it has a less acute/peaky curve of adenosine blocking.

I'm not a biologist, but I'm under the impression that your body uses the heuristic of "the more acutely a neurotransmitter is suddenly flooded into our system, the more of a homeostatic counter-response we're going to launch in the form of things like dopamine downregulation (etc, depending upon what neurutransmitter we're talking about)".

I'm not entirely sure this is true, but it seems to be corroborated by other researchers (e.g. Anna Lembke in her book Dopamine Nation, which isn't about caffeine though).

This is why substances like theacrine claim to offer even less tolerance than paraxanthine: it has a super gradual adenosine-blocking curve, with super long half-life (like 12-16 hours, IIRC). So when you take one theacrine, you won't notice it for hours, but its effects will last longer than one day (though I forget what its interaction with sleep is supposed to be?).

Some explanations considered in this video:

1. Software engineering isn't "real" engineering.

2. Nobody cares about bugs when they write software in the first place.

3. Software is hard.

4. Software is early.

This was such a great story.

Steve was a mischievous person himself, so surely a part of him respected this.

This is so cool. Real-time accent feedback is something language learners have never had throughout all of human history, until now.

Along similar lines, it would be useful to map a speaker's vowels in vowel-space (and likewise for consonants?) to compare native to non-native speakers.

I can't wait until something like this is available for Japanese.

What kinds of speed can be achieved, in terms of words per per minute?

Is this really how SOTA LLMs parse our queries? To what extent is this a simplified representation of what they really "see"?

Does anyone know if NOVAMIN based toothpastes (e.g. Sensodyne) have been tested?

The author should make a meta-entry about how he makes the (insanely beautiful) diagrams in the book (ideally walking through the process).

Insane that people would downvote a totally reasonable comment offering a competing alternative. HN is supposed to be a community of tech builders.