engined

The WebMD article is referencing esketamine, also known as Spravato, which is an FDA authorized form of ketamine. It's generally indicated for longer-term use in patients with Treatment Resistant Depression (TRD), and has really good results on par with ketamine (IV or intramuscular).

At Lumin Health, we treat about 80% of our patients with esketamine, and the rest with ketamine (generally only if they don't meet esketamine criteria). After the initial course, patients tend to find a good balance of ongoing care that helps treat their particular depression / depressive symptoms. This happens less with ketamine since it tends to be prohibitively expensive to continue care (upwards of $1k/month).

After dealing with depression myself, I dove deeply into this world, and actually ended up founding a ketamine and esketamine treatment startup in the Boston area (lumin.health). We've seen pretty amazing results with patients who have otherwise failed antidepressants and/or ECT and TMS (Transcranial Magnetic Stimulation). The reality is that ketamine/esketamine are much more accessible from a patient perspective, and while considered "new" by many in the medical community, offer faster results and carry less stigma for patients than ECT in particular. If ketamine/esketamine don't work, patients typically know within 2-3 sessions, and can walk away with no long term side effects. With ECT, patients generally have to complete a whole course before they see effect, and then are stuck with some of the potential mid/long-term side effects.

The space is also at the precipice of a whole new class of psychedelics coming online - MDMA, psilocybin, and more are all 1-5 years out (working through FDA drug trials), and hold promise of both faster results (versus 6-8 months of trialing traditional antidepressants) and fewer downside risks (versus weight gain, sex drive, etc. issues with antidepressants and memory loss, headaches, etc. with ECT and TMS).

Bottom line, if you're suffering and considering those treatments, I highly recommend finding a local center and at least learning more about options available to you.

Edit: If anyone wants to talk, advice, etc., email is in my profile.

This is an area I have experience and expertise in. Look at Master License Agreements in Houston, Dallas, San Antonio, Charlotte. Some states also have uniform legislation snaking its way through the various bodies, including Virginia, Ohio, Washington, Minnesota, Colorado, Florida, and California. Some is driven by ALEC and/or the wireless carriers, so it may be aggressively pro-deployment (to the detriment of local cities), but it's at least somewhere to look. If you're interested, PM me and I can share some materials on this, or at least discuss further.

Travel. Extensively. You will never regret it, you will always remember it, and you will always have a story or 10 to tell people when socializing. Parts of the developing world (India, Thailand, parts of South and Central America) are still cheap enough, and interesting enough, that you can get by on $1,000 or so a month while still living relatively well. I spent several months traveling >4 years ago while transitioning between both job and countries, and still talk and think about it often.

You're definitely right about case/precedent information, but what we've found is that there's a whole other world of info that can be neatly organized with a lot of crunching, and a small bit of manual manipulation.

The big guys chasing this are highly focused almost entirely on lawyers, in the context of providing them case analysis tools. We've found a bit of a different niche which doesn't need as much fidelity/granularity to the information, but needs it nonetheless.

In any case, I'd love to chat about your experience, even if a decade old. Can I PM you?

RECAP hasn't been nearly as active as its initiators had hoped. The data there is pretty good however, and for a handful of key cases, I would say it's very good. The biggest issue with the data is that it's spotty. Since it relies on individuals to pull info on each case, some cases may only have partial information (not all the parties, attorneys, etc. represented), or not have the full docket available (and rarely, if ever, all of the documents associated with a case).

PACER is definitely interesting, a bit antiquated, and to date, the data has mostly resided in the hands of the big information companies (Lexis, Westlaw, etc.).

I've been building a system/website to access, search and develop intelligent analytics from PACER court information. We're tracking cases, attorneys, parties, judges, as well as the actual case dockets. The data is a treasure trove of information, and if anyone's interested, I'd be very happy to chat more about it.

The site (a signup for now as I'm working out the kinks in the system) is www.docketleads.com. Email me there or ping me here for more info.

I'd be very interested. Please contact me at the email in my profile.

SEEKING FREELANCER - Boston/Cambridge, MA

Looking for a data scientist / developer to help in analyzing, and building some visuals around a pretty interesting dataset (65,000+ court cases and their associated data -- judges, parties, attorneys, dockets, etc.). This is early stage, experimental, a bit greenfield, and so far a lot of fun. There's a decent amount of statistical correlation to figure out, and also potential for some textual analysis to be done.

The intent is to eventually convert some of the more interesting analyses into visuals for presentation online.

Dataset currently resides in Postgres and the language of choice is Python (so Pandas, NumPy, NLTK (maybe?),etc.)

I'd prefer someone local (Cambridge) so we can do some work in tandem, but if remote is the only possibility and there's a good case for it, willing to try.

If interested, email me at [email protected]

[EDIT] Fixed email address to a working one

Good luck out there!