delton137

The Rapid Deployment Vaccine Collaborative (Radvac) has been doing some important work on bringing back and modernizing variolation.

While vaccines are clearly superior to variolation, variolation techniques can be applied immediately at the site of an outbreak. Vaccines, by contrast, take months to years to be developed, manufactured, tested, approved by the FDA, and deployed. During that time, viruses can spread and mutate, harming and killing many people.

Radvac believes that variolation deserves a new look — many scientific learnings from virology and immunology can be applied to make variolation safer and more effective. Here, Radvac co-founder and chief scientist Preston Estep reports on new self-experiments he conducted using hydrogen peroxide for virus inactivation and antibiotic ointment (neomycin) as an adjuvant. Two different delivery methods are explored - nasal insufflation and transdermal application using a cheap microneedle dermal roller. In a complementary whitepaper, Radvac has published detailed protocols for others interested in testing these methods. (link to the post below)

New on my Substack: how sleep optimization can backfire, five types of insomnia, and why I don’t recommend the Eight Sleep mattress cover.

Yeah, I agree. Not to mention TPUs and ASICS for AI.

Hi.. original post author here.

Interesting point RE the Snopes trial. You are right, evolution is not mentioned in the book as far as I can tell. Even though it is foundational to understanding the human body (in particular some weird features it have which any half-good creator would never design that way.)

The SJWs / woke cult are a bit of a personal hobby horse for me. I think it is important to mention, since woke ideology comes from academics at top universities, as well as journalists at top media outlets -- people who have a lot of power to shape the public discourse and influence public policy. The power of Christian fundamentalists over society and culture, on the other hand, has been waning, if one looks over the past few decades. Yes, they are in the ascendancy at the moment with the 2024 election and whatnot, but overall their influence is waning. Of course, both anti-science from the left and from the right are issues we should worry about -- I'm just giving an argument why we might want to be a bit more worried about anti-science from the left. How much either issue is discussed probably greatly depends on what circles you run in.

Note I did mention how there is no discussion of sexual health or women's health in the book. That is an issue with health textbooks that has been improved a lot but still exists to some extent today due to Christian conservatives.

I discuss three leading contenders for FDA Commissioner who are getting a lot of attention right now, Joseph Gulfo, MD, MBA, Balaji Srinivasan, and Jim O'Neill. Among these, my favorite is Dr. Gulfo, although I see a very strong case for Balaji as well.

say more? (main author here)

Article co-author here... that's super interesting. Would you mind sharing your condition? There's probably better things out there whatever it is...

Cerebrolysin = pig brain snake oil

"Cerebrolysin is an unregulated medical product made from enzymatically digested pig brain tissue. Hundreds of scientific papers claim that it boosts BDNF, stimulates neurogenesis, and can help treat numerous neural diseases...

A recent video of Bryan Johnson injecting Cerebrolysin has over a million views on X and 570,000 views on YouTube. The drug, which is advertised as a “peptide combination”, can be purchased easily online and appears to be growing in popularity among biohackers, rationalists, and transhumanists. The subreddit r/Cerebrolysin has 3,100 members."

HPLC and other evidence shows that rather than containing neurotrophic peptides, "Cerebrolysin is likely composed of amino acids, phosphates, and salt, along with some random protein fragments."