confiscate
Joined 12 years ago
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Member since
May 27
Guy working at a startup in the bay area
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Comment · 6 years ago
as an extreme example
if Remdemsivir cures 100% of all Covid-19 cases, halfway through the trial, they would have enough data to show a net positive benefit. They don't need to finish the whole trial to declare Remdemsivir useful
the fact that they are running the whole trial to finish, most likely means the effect of Remdemsivir is not too noticeable. They need more data to get to statistical significance. Hence, they want the trial to run to original planned finish date.
my guess is
Remdemsivir probably has some positive effect. Say, 10% lower death rate if used during 1st few days of infection. Still great, much much better than our current situation of nothing. It would not cure Covid completely, but it would help substantially, especially in large populations of infected
Comment · 6 years ago
yes but, if in a trial, if one arm performs substantially different than the control arm (e.g. 50% or even 100% lower death rate), the large difference between arms can lead to investigators ending the trial early
ironically, this happened in a previous 2019 trial of Remdemsivir, for a different virus, Ebola
in that trial, 4 drugs for Ebola were tested, including Remdemsivir. 2 non-Remdemsivir drugs succeeded substantially--the large difference between those drugs and Remdemsivir, was enough to cause the investigator to end the trial early and drop Remdemsivir
ironically, the investigator for that trial was none-other-than Dr. Fauci. Maybe that's why he hasn't mentioned Remdemsivir much on TV these days, based on his past professional disappointing experience with Remdemsivir
also, double ironically, Remdemsivir was initially designed to treat Ebola virus, not for flu or coronavirus type viruses. The fact that after the Ebola trial, Remdemsivir was declared not that effective for Ebola (the very virus Remdemsivir was created for), means there is even less of a chance Remdemsivir will prove to be effective for Covid-19 in the current trials
https://www.sciencemag.org/news/2019/08/finally-some-good-ne...
Comment · 6 years ago
can't laugh when you are breathing with your mouth, my friend :)
Comment · 7 years ago
care to give some examples? Because I am a curious reader who does not live in Iceland and don't have the context to be able to identify the embellishments
Comment · 7 years ago
consumers vote with their wallet, at the of the day.
by and large consumers don't care if the company is for social change or not.
it's difficult for a company to succeed in getting customers to pay based purely on social change intentions. That's how a market works
Comment · 7 years ago
that makes no sense
like you said in 2008 there wasn't anything there. They lose millions the whole company dies
now Tesla operates in billions of dollars. They lose billions it's still only 10%
Comment · 7 years ago
by that logic, the 1st email was "leaked" intentionally?
The 1st leaked email about burning cash over 10 months, causing the stock to crash even more
"where there's a will there's a way". So by your logic he wants the stock to go down
Comment · 7 years ago
Maybe the 1st email was leaked intentionally, according to your logic?
The 1st leaked email about burning cash over 10 months
How convenient that email leaked when the stock price is getting clobbered, adding insult to injury.
How convenient
Comment · 7 years ago
is this true?
Comment · 7 years ago
in reality he is getting paid minimum wage. He only gets stock if he hits milestones that are set impossibly high
Comment · 7 years ago
First of his name. Protector of the realm (of the valley) :)
Congrats Geoff! Much deserved. Looking forward to seeing great things at YC
Comment · 7 years ago
Agree. Do you think price is the limiting factor for lackluster demand? Maybe if they can make model 3 cheaper than 35k demand will rise
Comment · 7 years ago
Wait where are the links to these analysts?
The original post and every article online is citing Elon's email
Sensational headlines declaring Elon says Tesla will die, are headlines that generate clicks and views