ckw
Joined 13 years ago
Joined 13 years ago
Group Wealth Income/yr Spending/yr
50–95% ~$75–80T ~$11–13T ~$9–11T
95%+ ~$95–105T ~$7–9T ~$5–7T
75–85% ~$18–22T ~$2.5–3.0T ~$1.4–1.8T Year Male Female
1970 58% 42%
1975 53% 47%
1980 48% 52%
1985 46% 54%
1990 45% 55%
1995 44.5% 55.5%
2000 43.9% 56.1%
2005 43.3% 56.7%
2010 43.0% 57.0%
2015 43.6% 56.4%
2020 42.7% 57.3%
2025 42.7% 57.3%
So men have been in the minority for at least 46 years, and the skew is as large as it was in 1970, but reversed.Last month:
128 files changed, 39663 insertions(+), 4439 deletions(-)
Range: 8eb4f6a..HEAD
Non-merge commits: 174
Date range (non-merge): 2025-12-04 → 2026-01-04 (UTC)
Active days (non-merge): 30
Last 7 days: 59 files changed, 19412 insertions(+), 857 deletions(-)
Range: c8df64e..HEAD
Non-merge commits: 67
Date range (non-merge): 2025-12-28 → 2026-01-04 (UTC)
Active days (non-merge): 8
This has a lot of non-trivial stuff in it. In fact, I'm just about done with all of the difficult features that had built up over the past couple years.On the other hand, I watched family members take these drugs, and their lives seem somehow dulled-- filled with banal tragedy, like staying in a bad marriage, or not being particularly interested in their grandchildren. I have a theory that the drugs make palatable that which otherwise wouldn't be, hence they stay in the bad marriage, the bad job, and they watch their bad TV and eat their bad food and everything is fine. I've also seen one of them go off the drugs, and for a couple months they were a much more vibrant person. I saw them express joy. I feel a low grade rage toward the industry that I've been deprived of this version of them. I do entertain the possibility that I'm imagining it all. Maybe things really would have been worse without the drugs. But I am glad no one ever insisted, or even strongly advocated I take them myself.
'AstraZeneca LP and AstraZeneca Pharmaceuticals LP will pay $520 million to resolve allegations that AstraZeneca illegally marketed the anti-psychotic drug Seroquel for uses not approved as safe and effective by the Food and Drug Administration (FDA), the Departments of Justice and Health and Human Services’ Health Care Fraud Enforcement Action Team (HEAT) announced today. Such unapproved uses are also known as "off-label" uses because they are not included in the drug’s FDA approved product label.
[..]
The United States alleges that AstraZeneca illegally marketed Seroquel for uses never approved by the FDA. Specifically, between January 2001 through December 2006, AstraZeneca promoted Seroquel to psychiatrists and other physicians for certain uses that were not approved by the FDA as safe and effective (including aggression, Alzheimer’s disease, anger management, anxiety, attention deficit hyperactivity disorder, bipolar maintenance, dementia, depression, mood disorder, post-traumatic stress disorder, and sleeplessness). These unapproved uses were not medically accepted indications for which the United States and the state Medicaid programs provided coverage for Seroquel.
According to the settlement agreement, AstraZeneca targeted its illegal marketing of the anti-psychotic Seroquel towards doctors who do not typically treat schizophrenia or bipolar disorder, such as physicians who treat the elderly, primary care physicians, pediatric and adolescent physicians, and in long-term care facilities and prisons.
[..]
The United States contends that AstraZeneca promoted the unapproved uses by improperly and unduly influencing the content of, and speakers, in company-sponsored continuing medical education programs. The company also engaged doctors to give promotional speaker programs on unapproved uses for Seroquel and to conduct studies on unapproved uses of Seroquel. In addition, the company recruited doctors to serve as authors of articles that were ghostwritten by medical literature companies and about studies the doctors in question did not conduct. AstraZeneca then used those studies and articles as the basis for promotional messages about unapproved uses of Seroquel.
"Illegal acts by pharmaceutical companies and false claims against Medicare and Medicaid can put the public health at risk, corrupt medical decisions by health care providers, and take billions of dollars directly out of taxpayers’ pockets," said Attorney General Eric Holder. "This Administration is committed to recovering taxpayer money lost to health care fraud, whether it’s by bringing cases against common criminals operating out of vacant storefronts or executives at some of the nation’s biggest companies."
The United States also contends that AstraZeneca violated the federal Anti-Kickback Statute by offering and paying illegal remuneration to doctors it recruited to serve as authors of articles written by AstraZeneca and its agents about the unapproved uses of Seroquel. AstraZeneca also offered and paid illegal remuneration to doctors to travel to resort locations to "advise" AstraZeneca about marketing messages for unapproved uses of Seroquel, and paid doctors to give promotional lectures to other health care professionals about unapproved and unaccepted uses of Seroquel. The United States contends that these payments were intended to induce the doctors to prescribe Seroquel for unapproved uses in violation of the federal Anti-Kickback Statute. '
The takeaway is that anytime a physician prescribes you a drug, at the very least you have to check that there hasn't been a gigantic fine levied against the drug maker for illegally tricking your doctor into prescribing it to you.
Lower bone mineral density, increased risk of fractures, osteoporosis
Sexual dysfunction / PSSD (Post-SSRI Sexual Dysfunction)
extra pyramidal symptoms (akathisia, Parkinsonism, dystonia, tardive dyskinesia)
emotional blunting / apathy
slowed thinking, brain fog
increased risk of gastrointestinal bleeding
QT prolongation
Edit: in case the OP is reading, I should say also that the package insert won’t mention many other potential long term effects addressed in the literature, like extra pyramidal symptoms (akathisia, Parkinsonism, dystonia, tardive dyskinesia).
Another edit: ask GPT-5 ‘What are the long term side effects of Prozac use which aren’t addressed in the package insert?’ for a list.
So should I not have done my own research?
‘Highlights
• Antidepressant withdrawal can be severe and protracted.
• It produces characteristic physical and emotional symptoms.
• All symptoms were more severe after stopping than before starting antidepressants.
• We identified the 15 most discriminatory withdrawal symptoms in our sample.
• Withdrawal did not differ between people with physical or mental health diagnoses.’
‘Warning: Suicidality and Antidepressant Drugs
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults taking antidepressants for Major Depressive Disorder (MDD) and other psychiatric disorders’
Read the package insert: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/01...
The fact that you were not informed about this should serve as proof that you cannot blindly trust what doctors tell you. They will absolutely kill you out of ignorance or incompetence, and never even realize their responsibility.