asafira

Isn't there TRT that doesn't impact your endogenous production? (HCG, SERMs)

There is large-enough consensus on this drug for its main use cases (treating diabetes and obesity), but more importantly for this conversation: it's actually quite common for drugs to get new indications after their initial one --- at which point, there might be a new, broader consensus on what the drug is good for.

Clinical trials are designed to treat a very specific subclass of individuals; pharmaceutical companies very carefully choose that subclass in an attempt to help ensure the clinical trials are successful, which is a combination of the following:

- Positive, statistically-significant results. - FDA approval with those results. - Insurance companies willing to pay for the given treatment. - A decent-sized addressable market.

Examples of drugs/medical technologies later getting other indications: - Minoxidil was a drug that only later got its approval to be used as a hair loss treatment; there are currently clinical trials for a more "advanced" minoxidil oral pill for this use case. - Re: GLP-1s: Tirzepatide later got an indication that it effectively treats sleep apnea. There are very many other clinical trials ongoing for GLP-1s, but perhaps most recently, Semaglutide (ozempic) failed to show statistical significance as a treatment for Alzheimer's. - The Galleri blood screening/test. The initial indication they are going for is folk who are at highest risk for cancer (I believe that's individuals between the ages of 50 and 70); however, that's not to say it would be bad for individuals younger or older. But, this is a way to help ensure the earliest product has a successful outcome.

These are ones I know off the top of my head, but I suspect an LLM can give several more examples.

He worked mostly on the software side, but of course had important input into what sensors and processors were chosen for the phones.

Even better if it is actually a usb stick, too.

This might be the silicon valley bubble here though.

I am sorry you feel that way =/; I understand it was a picky comment, but quibbling over it is far from the gross overstatement you mentioned.

I've read before that they used to use the sound of bacon cooking on a skillet to mimic the sound of rain in movies. I think I can hear it...

From the post: "Ray tracing was invented by Turner Whitted around 1980."

I believe that Turner probably did some great things, but somehow I don't think I believe he invented ray tracing. Ray tracing has been around for so long in physics...

For intermediate E&M, Griffiths Electrodynamics.

It seems to me like when I type in company names, I don't get the exact colors they use in their branding...

I often get asked about what my views on doing a PhD are (I am more-or-less finished with one now), and one of the ways I frame it is the following:

You know how you've take a course before where the professor was just surprisingly awful at teaching? These professors are often some of the most knowledgeable people in a subfield of the subject you are taking, yet their teaching ability is severely lacking and you have to scramble to learn the material some other way (or just never learn it).

During a PhD, there is a decent chance that your adviser is similarly a bad manager. Unfortunately, having a bad manager for 5-7 years of your life can be a fairly awful experience. You will work with someone who you, on the one hand, look up to, but on the other hand, who seems to not care at all about your mental health, your possible career desires outside of academia, your work/life balance, or the exact reason why this week was a rough week for research in your (human) life.

I have a lot of other thoughts on the matter, but I thought I'd try to keep this post more concise =).