Wonnk13

stage 4 colon cancer here... Pancreatic cancer is obviously a _very_ different disease, but when i was diagnosed just about a decade ago the conventional wisdom was that KRAS was basically undruggable. I'm KRAS 12D and very excited for future.

No it's not a cure, but this drug is the difference between someone's mother or father making it to one more Christmas, or Birthday, or other life milestone.

not that it really matters, but is he leaving Google?

I'm not surprised. K shaped economy, any sector that isn't high tech / AI is stagnant. It's rough out there. I've been saying since Covid, retailers have figured out some consumers aren't as price sensitive as previously thought. WholeFoods doesn't need to cut prices, but the lower tier grocery stores will really feel the cutbacks.

I wish them all the best. Supabase, Timescale, etc etc. there's a whole cottage industry of extending postgres to whatever you need.

I don't know what it is about Chicago, but I find I have an insatiable curiosity about everything. I've never thought much about bridges, but when I'm in the loop I just stare at them sometimes. I love the architecture, the parks, the bike lanes it's just too bad it's in Illinois ha!

Chicago in February is indistinguishable from Hoth.

yea I'd +1 this. It's a real blindspot in the author's writing. I don't think you can write about meditation in the US without mentioning IMS. Headspace and all the other mcmindfulness apps that start with "focus on your breath" are all derived from Insight meditation. I've sat IMS, it's an incredible facility.

When I think of LLM / Agent observability I think of some combination of open telemetry and like Influxdb, but I don't think that's what your asking for?

nothing more than a n=1 anecdote, but I'm noticeably more depressed when my wife is in the office and I don't go in to a coworking space and/or do something with my friends after work.

Even as an introvert I can easily see if I didn't have a partner and access to friends and socialization I'd be significantly more likely to kill myself.

Before my mother started joining more retiree clubs I could literally see on her face how much more weathered and haggard she was. The isolation was physically visible on her face.

wow; I'm not a gamer at all. never owned a console since my parents bought one for my brother and myself over two decades ago. I might (5-15% chance) pick up a ps5 just for flightsim and the new GTA. RIP xbox

Maybe I'm overstepping, but I think 1. you're right 2. that it's driven by insecurity. I've experienced many instances of people trying to "protect their knowledge" so to speak by hiding behind jargon.

I was a refugee of the Great Digg Migration to reddit some 14 or so years ago. old.reddit and adblockers as well as very aggressive curation of subreddits have kept it to an overall positive experience over the decade.

I think overall I'm just less enthusiastic about the internet; everytime I come back from a week or two of backpacking without internet connection I realize how overstimulated with inane bullshit we all are.

This is why I'm not a consultant. It's a generalization, but there's a kind of learned helplessness almost in the culture of the big4. Client has a new requirement, and someone says "oh guess it'll be an allnighter, i'll start ordering pizzas". Nah man, this is like four extra hours of work- push the deadline, or just work smarter.

come back in the winter and ski Tucks! if ya aint freezin and dying it aint fun yet