Vera_Wilde
Joined 1 year ago
Joined 1 year ago
If anyone works in health tech, security, or trust & safety, I'd also love to hear how this maps to your practical experience with low-prevalence detection.
If you test the simulator, I'd love to hear what surprised you most — especially if something behaved differently than you expected. Thanks in advance!
The purpose is to begin to more easily visualize how prevalence, sensitivity, specificity, investigative capacity, and strategic behavior interact to shape real-world outcomes.
Interactive tool: https://verawilde.github.io/rarity-roulette/
Would love feedback, critiques, and ideas for improvements.
So one thing missing from the excitement around this line of work: how little these worm effects generalize to mammals.
C. elegans has very unusual biology — direct soma→germline communication pathways, minimal nervous systems, and short generational cycles. Epigenetic inheritance is much easier to observe there than in mice or humans, where mechanisms differ and dilution across meiosis tends to erase these “marks.”
This means that, even if the PA14 avoidance effect replicates, it’s not evidence that humans inherit learned behaviours. It’s evidence that worms are an interesting edge-case system.
Curious if others are seeing this kind of “shadow regulation” pop up more frequently elsewhere — especially in email filtering, CDN layers, and AI content moderation.
Yeah, the bonobo/chimp contrast shows it’s not an inevitability. We just optimized for the wrong equilibrium.
The thing I always want from timezone tools is: “Let me simulate a date after one side has shifted but the other hasn’t.”
Humans do badly with DST offset transitions; computers do great with them.
The Zombie proposal just keeps rising from the dead. The technical/mathematical objections don’t change.
I still haven’t seen a counter-argument stating why a mass-scanning architecture should be expected to work, given the base rates and error rates involved.