Thebroser
Joined 7 years ago
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217
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26
Member since
May 14
Recent submissions
Comment · 1 year ago
The approach they used which is base editing doesn’t actually insert or remove DNA, it actually uses an enzyme to convert one base to another, which is much safer as this doesn’t require a double strand break in DNA: https://blog.addgene.org/single-base-editing-with-crispr
Comment · 1 year ago
Add gene has a great guide as to what goes on at the molecular level: https://www.addgene.org/guides/crispr/
Essentially you can design an rna molecular that contains a 20 nucleotide long sequence that can target your region of interest, with the caveat that there is a standard recognition sequence proximal to your sequence of interest (PAM sequence)
Comment · 2 years ago
I used to love this chrome extension back in the day, unsure if it still works but same idea:
Comment · 2 years ago
Home lab, or even be able to sequence your genome at home, privately and securely without risking giving your genetic information to companies like 23andme
Comment · 2 years ago
There’s also people pursuing mRNA delivery systems to do this. Might be cheaper than viruses and there’s precedent now with COVID vaccines. https://www.capstantx.com/
Comment · 2 years ago
There are research groups that are trying to encode genetic neural networks into cells like the example I have attached, but the neuronal approach from the post does seem to be different here. https://www.nature.com/articles/s41467-022-33288-8
Comment · 3 years ago
Would probably assume some level of immunosuppressants might be necessary.
Comment · 3 years ago
There are definitely very solid attempts at least to make LLMs that encode biomedical knowledge such as BioGPT which is trained on Pubmed and other domain specific areas. Source: https://arxiv.org/abs/2210.10341
Comment · 3 years ago
Spatial Transcriptomics. Being able to see gene expression at a resolution of a handful of cells in a cross section of tissue is revolutionizing disease research. https://www.nature.com/articles/s41592-020-01033-y
Comment · 4 years ago
I am always fascinated by the ignorance that is blatantly displayed on HN when it comes to biotech advancements. Not even some actual criticism of the tech, or even the faint understanding that this sort of thing is exploratory research. Wonder why this sort of skepticism is never applied to cutting edge AI research whose ethical ramifications are much more severe and which is already being utilized by bad actors to facilitate genocide [1].
[1] https://wires.onlinelibrary.wiley.com/doi/abs/10.1002/widm.1...
Comment · 4 years ago
“Animal research has shown that natural cochlear hair cell regeneration and resultant hearing restoration is very real” - Although exciting, we also need to remember that translatability rates from animal models to humans is notoriously low, usually in the single digits for most therapeutic areas. This is some cool tech, but just wanted to point it out that success in animal models =/= we will eventually get to see the realized treatment.