Mitchhhs

I wonder if a similar proportion of drugs that work in Humans wouldn't work in mice. Are we missing out on a ton of potential?

This is a misconception that kind of bugs me. At the top schools they give a tremendous amount of need-based grants (i.e. money that never needs to be paid back). Elite institution grads are not the ones who have debt they can't pay back. Its people at middle of the road private institutions and many other scenarios that have this issue. You are confusing the sticker price with what the bulk of non-rich students actually pay which is far lower. This narrative bugs me because it is just incorrect and focuses on the wrong places as sources of a very real issue.

Its not always being just informed. Its the difference between knowledge and wisdom. You may know all these things up front and make the same decision to take VC because of other factors, prestige, the easy money, thinking you will be the billion dollar company. Then things don't go as planned, the rubber meets the road, and the cool sound of telling people you raised VC wears off. Then you realize why all of these articles are written and write one yourself.

Cannot agree with this more, thanks for articulating this so well. I definitely learned this lesson over time. In the beginning I just thought my lawyer would tell me what I should do. Then I realized that I should figure out what we should do and how I thought it should be structured and then use my lawyer to give advice, figure out how to accomplish what we wanted to do, and make it happen. It made the whole process more fun since it was nice to feel comfortable reading legal documents and thinking through the issues and everyone ended up better off.

Because a few teachers are instagram influences doesn't mean that "Teachers" as a profession are doing this widely. You could pretty much replace the word teachers with any profession and this would probably hold true.

Yeah but thats different. Theres a difference between charging zero to get a network and losing money as a business vs selling a product and losing money on every single unit of that product being sold.

Yeah that's the problem here its really hard to tell the difference between the two. Sometimes it feels like a "new economy" excuse.

Question, what is a good example of a market place that is now highly profitable where the unit economics/contribution margin were negative for a very long time.

Amazon is not an example, I guarantee they were making contribution margin on every book sold fairly early on.

"Xu said the company became “contribution margin positive” in the last year, which means that it’s profitable on a per-order basis. In fact, DoorDash has become profitable in its earliest markets."

Its funny this is a milestone for a company at this stage. Congrats you aren't losing money on every order!

I don't like when titles obscure the actual findings. It should be Alcohol abuse largest risk factor for dementia. Its not just drinking alcohol, its drinking alcohol problematically.

I feel like journalists are just trying every way possible to create an anti-tech sentiment. Crazy how fast things can change from all hail the tech titans to oh these tech companies are creating a dystopia. Theres way too much noise in every aspect of information these days to help society focus on the problems that actually matter.