ClaraForm

This is beautiful, thank you!

I just asked Deepseek 4.1 Flash to convert it to an Obsidian extension that uses the file-name as the seed, and the result [1] is exactly something I've been dreaming of for so many years while I take daily notes.

[1] imagepaste.org/i/8zu627ud.png

Lately I haven't been very happy with Kagi. A few searches have completely failed for me returning a blank page when both DuckDuckGo and Google had a response. The Kagi translate on/off switch made me think their services are unreliable. Then this happens and it feels like more that their word is unreliable. They expanded into too many domains and spread themselves too thin and that doesn't give me confidence.

My subscription is up for renewal in December and I think I actually have a decision to make. For now I'm very happy with the Kagi MCP for my research agent. But I'm definitely having a moment of "how reliant should I really be on this company?"

As a neuroscientist: no. Not what I mean.

Right? Where's the substrates of consciousness, or the actual solutions for protein/rna folding, or the requirements for evolution?

Right? "Go find outsized success, but I'm going to put a non negotiable cap on the size. You can pick a bad direction for good reasons, but only you will be responsible if there are no good directions."

To be more clear: Failure can happen due to both internal and external forces. This advice enshrines internal power structures and ensures their systemic faults are permanent. It's not a seat at the table if you don't have a say.

You’re getting awfully close to being rude. There’s no reason to try to go around imposing your perspective when it’s just you venting about feeling stuck. We all feel stuck from time to time, the solution is generally to wait it out until something that genuinely excites you comes along and you ask to hop on that opportunity. That’s possible in all work cultures, including egalitarian flat organizations.

Thank you for that! I think I read about this a long time ago, internalized it, and forgot it. Pretty on the nose in this conversation... haha.

Hey, I know what the article wanted to say, see the last two-ish sentences of my previous response. My point, is that the article might be mis-interpreting what the causes and solutions for the problems it sees. Relying on the brain as an example of how to improve might be a mistaken premise, because maybe the brain isn't doing what the article thinks it's doing. So we're in agreement there, that the brain and LLMs are incomparable, but maybe the parts where they're comparable are more informative on the nature of hallucinations than the author may think.

Yes, I agree. I'm not against the idea that the brain can "store" things. Just whether our concept of how a "memory" "feels" is useful to us further understanding the brain's function.

I mean an LLM (bad example, but good enough for what I'm trying to convey) doesn't need any sort of "memory" to be able to reconstruct something that looks like intelligence. It stores weights, and can re-assemble "facts" from those weights, independent of the meaning or significance of those facts. It's possible the brain is similar, on a much more refined scale. My brain certainly doesn't store 35,000 instances of my mum's image to help me identify her, just an averaged image to help me know when I'm looking at my mum.

The brain definitely stores things, and retrieval and processing are key to the behaviour that comes out the other end, but whether it's "memory" like what this article tries to define, I'm not sure. The article makes it a point to talk about instances where /lack/ of a memory is a sign of the brain doing something different from an LLM, but the brain is pretty happy to "make up" a "memory", from all of my reading and understanding.

I'm not convinced the brain stores memories, or that memory storage is required for human intelligence. And we "hallucinate" all the time. See: eye witness testimony being wrong regularly, "paranormal" experiences etc.

It's a statement that /feels/ true, because we can all look "inside" our heads and "see" memories and facts. But we may as well be re-constructing facts on the fly, just as re-construct reality itself to sense it.

I think the play was something along the lines of being "the new iOS". Lots of new apps (see: LLMs) are browser-first, forgoing building platform-targeting apps entirely. When they couldn't see any app devs lining up to build Arc-specific extensions, apps, or such, they pivoted. Dia was more of an LLM-host browser, with the play being they're hoping for OpenAI or Perplexity or one of the big foundation-players to "pay" to be the "exclusive" AI provider, like old-Google pays to be the default on Safari. But ... both plays didn't find any audience or customer, rightly so, as they didn't try to "fix" anything anyone actually considered a problem, just tried to build a niche their own. :(

As someone who grew up in Dubai, the tourism industry everywhere breaks the soul of the place. Dubai, especially the places where people actually live and set up a livelihood, is a place like any other.

What a terrible day to be literate and be able to read into the ugly belly of self-righteousness disguised as morality.

Other commenters are wrong. Live-cell can be done with older single-molecule localization microscopy using techniques like PAINT. The fluorophore is usually strategically added in a way that binding-unbinding events cause excitation. Algorithms can then infer identity of single fluorophores based on their excitation pattern/strength and can predict whether it's two distinct fluorophore molecules or the same molecule moving over multiple frames of image acquisition.