For better or worse, the ISA wars are in one sense over. There's relatively little benefit to be gained from using an architecture other than amd64 or ARM at this point; silicon has evolved to the point were the line between RISC and CISC is pretty much nonexistent, save for some minor benefits around code density etc. The benefits of using amd64 are beyond-compare experience of optimisation, commodity pricing, and legacy compatibility; the costs are negligible.
However, I'm somewhat uncomfortable with Intel's increasing and complete near-domination of the "not-low-power" CPU market. I'd love to see other high-end silicon designers start to develop amd64-compatible processors that will encourage competition in the market. AMD's struggling with it, but there's plenty of scope for looking at interesting approaches to increasing performance or reducing power use.
However, I'm somewhat uncomfortable with Intel's increasing and complete near-domination of the "not-low-power" CPU market. I'd love to see other high-end silicon designers start to develop amd64-compatible processors that will encourage competition in the market. AMD's struggling with it, but there's plenty of scope for looking at interesting approaches to increasing performance or reducing power use.