Ask HN: Why would or wouldn't you do a marijuana-focused startup?

A lot of HN is libertarian and I would assume that many would see no problem with doing a marijuana focused startup. Considering how much opportunity there is in this space, I'd expect to see a lot more companies (WeedMaps, Leafly etc.) pop up.

I can imagine some of the issues: - Family would frown on it - "Unfundable" - Difficult regulation - Not a "sure" thing

So HN, why wouldn't you do a Marijuana-focused startup?