It also surprises and bewilders me that businesses (usually tech or tech adjacent) apparently expect and have for some time expected the ability to do business internationally completely without friction. Which is less something I think is a good or bad idea, and far more just simply an unrealistic one. If you want to sell in a given set of countries, I would think it a given that you would have to deal with the regulations and business laws in each of those given countries. The fact that you want to sell hacker/DIY products to people in less developed markets is admirable, certainly, but it doesn't change that. It's an unsolved problem precisely because it's kind of a pain in the ass to do compliance work across a large number of them. It's why large companies have entire departments devoted to regulatory compliance.
As far as I'm concerned the only way you could say this is "killing" any business is if the business in question has, as you said, spent the last decade just assuming they could sell things wherever with no oversight.
As far as I'm concerned the only way you could say this is "killing" any business is if the business in question has, as you said, spent the last decade just assuming they could sell things wherever with no oversight.