The WASI support in CPython has moved along very well and it is an early target via componentize-py[1]. Notes on WASI support in Python can be found in PEP 816[2]; CPython will be jumping from 0.1 to 0.3 (0.2 is adapted in componentize-py) which should unlock a fair bit of support, especially once cooperative threads lands (providing a pthreads impl in wasi-libc).
[1] https://github.com/bytecodealliance/componentize-py [2] https://peps.python.org/pep-0816/