I've been working on a server-side wasm impl of cpython called boomslang [1] and have been thinking a lot lately about packaging, one of the downsides of my current impl is the need to statically link all c/rust extensions. Its too bad IMO how much of the wasm ecosystem targets/depends on emscripten directly. It'd be interesting to see if a more generic ABI could be provided for non emscripten/js based wasm runtimes.
[1] https://github.com/HubSpot/boomslang