Comment by porphyra

Darktable is great, but notably, it doesn't have any neural network-based denoising, even though that's now standard in Lightroom, Capture One, and other apps. Darktable only has rather outdated wavelet and non-local means denoising. So a photo that would be perfectly fine at ISO 6400 in other apps will still look grainy, or worse, splotchy in Darktable.