Color me a bit skeptical on the "GLP-1 is the cure for everything" hype. These drugs are clearly a game-changer for obesity and T2D, and possibly a few other conditions, but it strikes me as unlikely that a chemical exists that is more or less an across-the-board improvement to health, with no downsides. If it was that simple, why didn't the human body just evolve to excrete GLP-1 agonists? Or modify GLP-1 itself?
The best argument against is "starvation was a human universal" and that survival through famines totally dominated the evolutionary trend in GLP-1 related things in the body. But even something as simple as lactose tolerance responded quite quickly to changes in human dietary structure in different areas of the world.
My suspicion is that at least some of these medical record review studies are just driven by confounding - people who find out about GLP-1 agonists are better educated, wealthier, or have behavioral/lifestyle traits that explain many of the apparent benefits.
(still, part of me is still holding out for the "miracle drug" explanation)
The best argument against is "starvation was a human universal" and that survival through famines totally dominated the evolutionary trend in GLP-1 related things in the body. But even something as simple as lactose tolerance responded quite quickly to changes in human dietary structure in different areas of the world.
My suspicion is that at least some of these medical record review studies are just driven by confounding - people who find out about GLP-1 agonists are better educated, wealthier, or have behavioral/lifestyle traits that explain many of the apparent benefits.
(still, part of me is still holding out for the "miracle drug" explanation)