i have no idea what subtle or nuanced distinction you're trying to strike so what exactly do you imagine is the difference between a lisp repl and a python repl?
Edit: people that aren't familiar with python (or how interpreters work in general) don't seem to understand that being able to poke and prod the runtime is entirely a function of the runtime, not the language. In cpython you can absolutely do anything you want to the program state, all the way up to, and including, manually push/pop from the interpreter's value stack (to say nothing of moving up and down the frame stack), mutating owned data, redefining functions, classes, modules, etc. You can even, again at runtime, parse, to AST, and compile source to get macro-like functionally. It's not as clean as in lisp but it 100% gets the job done.
Edit: people that aren't familiar with python (or how interpreters work in general) don't seem to understand that being able to poke and prod the runtime is entirely a function of the runtime, not the language. In cpython you can absolutely do anything you want to the program state, all the way up to, and including, manually push/pop from the interpreter's value stack (to say nothing of moving up and down the frame stack), mutating owned data, redefining functions, classes, modules, etc. You can even, again at runtime, parse, to AST, and compile source to get macro-like functionally. It's not as clean as in lisp but it 100% gets the job done.