This probably doesn't count as "natively" but I've run ABCL[1] under Doppio[2]. Startup times are under a minute in Chromium based browsers and under an hour in Firefox. I've run into zero stability issues, but its no speed demon.
[edit]
Just tried again today and Firefox gets to a REPL in about 3.5 minutes, while chromium is still right about 1 minute.
[edit]
Just tried again today and Firefox gets to a REPL in about 3.5 minutes, while chromium is still right about 1 minute.
1: https://abcl.org/
2: https://plasma-umass.org/doppio-demo/