Nah. Historical vaccines effectively cover "what happens when we train the immune system to react to something via vaccination", which is still quite relevant with mRNA vaccines.
mRNA's short half-life - on the matter of a few dozens of minutes - and pre-existence in our bodies helps us not worry too much about the differences in delivery mechanism.
mRNA's short half-life - on the matter of a few dozens of minutes - and pre-existence in our bodies helps us not worry too much about the differences in delivery mechanism.