Yes! In our newsroom (which isn't perfect by any means) - I have been testing using Qubes for really sensitive/untrusted documents. We also open un-trusted documents (from e.g. FOIA responses) on a machine live-booting from a CD.
However, it adds enough friction (especially with remote work) that it's hard to get it right 100% of the time.
If you want to share really sensitive documents, one way to ensure proper handling of your documents is to use a service like SecureDrop [0] which for e.g. only accepts submissions over Tor and requires the use of a secure viewing station [1] (air-gapped machine live-booting Tails w coreboot rom + webcam/networking card physically removed) to decrypt/access leaks.
That being said, I don't think there's a perfect tech-only solution because nothing is stopping folks handling it carelessly after they access the file.
However, it adds enough friction (especially with remote work) that it's hard to get it right 100% of the time.
If you want to share really sensitive documents, one way to ensure proper handling of your documents is to use a service like SecureDrop [0] which for e.g. only accepts submissions over Tor and requires the use of a secure viewing station [1] (air-gapped machine live-booting Tails w coreboot rom + webcam/networking card physically removed) to decrypt/access leaks.
That being said, I don't think there's a perfect tech-only solution because nothing is stopping folks handling it carelessly after they access the file.
[0] https://securedrop.org/directory/center-public-integrity/
[1] https://docs.securedrop.org/en/stable/set_up_svs.html