Comment by Retric

That’s true on the surface, but there was a ~300 year gap between 1472 and 1763. By 1600 contact was widespread which should have been plenty of time to spread disease. https://www.oregonhistoryproject.org/articles/historical-rec...

So, native populations should have had time to develop immunity to European diseases. At even 2.5% annual population growth rate a population recovers from a 90% population drop in under 100 years.

https://www.oregonhistoryproject.org/articles/historical-rec...

Thus either disease was vastly more devastating than just 90%, genocide by Europeans was very intentional across generarions, or some other effect was in play.