They reason that 1) ARB doesn’t increase ACE2 past normal human baseline anyway, just to normal status 2) Younger have higher ACE2, older women more than older men; both groups more protected so disease severity unlikely from higher ACE2.
ACE2-fc being developed- will both stop AT1R activation and neutralize virus:
Best guess? ACE2 loss is probably bad, having more ACE2 probably doesn’t drive disease severity:
https://twitter.com/__philipn__/status/1229568317167243264?s...
Relative ace2 reduction correlates w disease severity; viral load growth the same between groups - check out study!
Chinese paper discusses this as well:
https://pubmed.ncbi.nlm.nih.gov/32061198-inhibitors-of-ras-m...
They reason that 1) ARB doesn’t increase ACE2 past normal human baseline anyway, just to normal status 2) Younger have higher ACE2, older women more than older men; both groups more protected so disease severity unlikely from higher ACE2.
ACE2-fc being developed- will both stop AT1R activation and neutralize virus:
https://twitter.com/robertlkruse/status/1233986542097567744?...
He is looking for funding if any funders are reading this. Comment here and I can connect.