- when the virus docks with the ACE2 receptor there is a loss of the ACE2 receptor function as it is a destructive process.
- when the virus inhabits the cell there is probably a cytoplasmic down regulation of ACE2 expression as the cell is now "claimed" as a place for replication
so the question would be when would we administer or withdraw such an ACE2 blocker
the loss of ACE2 functionality is devastating to the cell
but the presence of functional ACE2 receptor makes a cell vulnerable to entry
-and should we be using a blocker pe se or should we use some sort of hypothetical receptor inhibitor that is not displace by coronavirus spike protien, as in competetive inhibition?
- when the virus docks with the ACE2 receptor there is a loss of the ACE2 receptor function as it is a destructive process.
- when the virus inhabits the cell there is probably a cytoplasmic down regulation of ACE2 expression as the cell is now "claimed" as a place for replication
so the question would be when would we administer or withdraw such an ACE2 blocker
the loss of ACE2 functionality is devastating to the cell but the presence of functional ACE2 receptor makes a cell vulnerable to entry
-and should we be using a blocker pe se or should we use some sort of hypothetical receptor inhibitor that is not displace by coronavirus spike protien, as in competetive inhibition?