vancanwin

Hi Kayhi, quickly, what do you define people with normal diet? There is an array of different diet and different health spectrum that doesn't constitute a visit to the doctor or even have the thought of getting a blood panel. As mentioned above, the scientific rigor for each supplement efficacy on some human clinical trials are sometimes over-simplification of findings from very short trials that don't look into more longitudinal studies. And this is just the non-healthy populations. Most clinical trials that do work on healthy populations tend to focus on athletes. We are still looking more studies that focus on "average" populations that aren't necessarily unhealthy and pro athlete population.

In the end, what we are doing is using data to see if controlling for purity in supplementation improves people's definition of health. If we can control parameters (purity, vitamin active form, etc.), can we see those changes quantitatively rather than qualitatively.

Thanks for your inquiry.

To your first question, that was done on PhD work in human cell lines and plants. What you observe is the production of the active metabolite (E.g. thiamine converted into thiamine pyrophosphate) or breakdown of the metabolite.

We are looking into that research right now with our advisors. This is definitely an ongoing research topic especially related to inflammatory diseases and cancer. We aren't making any of those claims yet since it's still hard to interpret these studies in human cell lines and small population in some of the clinical trials (E.g. the study that saw increased efficacy of a cancer drug with vitmin c). We are conducting further investigation and research with PIs that are doing this type of work. But for now, we do not have a consumer product that can measure epigenetic changes dynamically.

We definitely notice this feature is lacking in the customer flow. We have a dosage generator in our backend that our customer received but we will push that feature to be more transparent in our metabolic assessment.

We are looking to improve our assessments by getting a sense what other lifestyle factors to include. A lot of customers and people going through the site has been helping us add other factors such as smoking, for example.

Not sure where you got that feature since that feature is not yet available online. We can generate a list of dosages that customized base on your body composition.

First, we include the vitamins base on a per package basis and that feature pops up after you've taken the metabolic assessment.

Second, yes that's the first genetic differences we are accounting for. My cofounder and I are both female founders with a set of MTHFR SNPs and have had issues with proper methylation of folic acid and even cobalamin. We currently include methylated cobalamin, but have had issues finding manufacturers that provide methylfolate (and not other derivatives such as methyltetrahydrofolic acid).

Our vitamins cannot be injected at the moment since most isoforms of vitamins are usually in an inactive form that requires absorption through the gut.

Yes! Absolutely and other factors from oxygen radicals to light exposure.

To address the difference between our formulation with liposomal vitamins, the difference is in the formulation of the vitamins working with each other not in the encapsulation. For example, most of packages includes Vitamin D3, calcium, and Vitamin K because calcium and vitamin K helps increase the uptake of Vitamin D3 through interactions with vitamin d receptor.

Ideally, we want to find manufacturers that produces liposomal vitamins, but haven't found any that doesn't use other fillers such as starch and sugar as well. Also not all supplements require an encapsulation process. The rate of vitamin C degradation is the fastest, hence why most vitamin c on the market is sold with liposomal encapsulation.

Yup totally working on it now. We are working through Cloudflare to setup the certificates. Thanks!

Which part? So I can help be more clear.

Thanks for your feedback.

(1) Our 10x claim is on efficacy of absorption as for liquids typically easier to absorb than tablets or soft gels. I will submit that article soon. Apologize for not being clear.

(2) As for measurable health improvements we are collecting those data through our customers and research done with our advisors at the moment. We have some preliminary results but are currently under review. Happy to share that once it is published.

We would love to get into vitamin manufacturing as we do see this epidemic of not validating purity of vitamins happening further down the line. We are partnering with third parties to help us provide certificate of analysis for the supplements we purchase from our manufacturers.

Yes thank you. Will edit it now.

I just realize that after responding again (see above).

We are definitely checking you guys out. We've spoken to Neil to set something up soon. :)