toufka

Subsidies for public goods create economic multiples. It’s not plainly obvious that it’s bad to subsidize a trip by $10. And compared to what? How much is interstate infrastructure subsidized per trip? Or airline infrastructure?

The new iOS rebrands Gemini as Siri - and from all accounts of the public beta, it's pretty decent, and an enormous upgrade from the current/old Siri.

The image size of this camera is unbelievably huge in its coverage.

Most telescopes take pictures of objects - this one takes pictures of the entire sky. And will do so in a time-lapse fashion for 10 years.

It's simultaneously more in line with a human's experience than an obscure wavelength of tiny object not visible to the naked eye - it takes a high-resolution picture that's similar to what you'd see if you look at the sky. But it's also profoundly grand beyond a human's experience because of just how much stuff is collected.

Also the fact that the president’s daughter, son in law, and his brother have a significant amount of their net worth invested in OpenAI via Thrive.

The administration is not known for taking into account second order effects.

The instantaneous instinct to strike an opponent when one can is not much more contemplated than that.

How much did Apple (via Google (via xAI (via SpaceX))) just crush their product?

Seems an awful lot like Apple will commoditize the models that power Siri, and just “sherlocked” a trillion dollar private company.

A large and rapidly growing number.

The largest commercial classes of multi-domain therapeutic proteins include the crispr (and similar) that drive gene therapies, and the chimeric antigen receptors (and similar) that drive cell therapies.

But lead optimization there look different than this page’s efforts.

I mean, the most cutting edge of iPhones, iPads and MacBook Pros _today_ are quite capable of running in realtime today’s high-end local LLMs.

If you project out that hardware just a couple of years, and the trained models out a couple of years, you end up in a place where it makes so much more sense to run them locally, for all sorts of latency, privacy, efficacy, and domain-specific reasons.

Not all that different from the old terminal & mainframe->pc shifts.

Finally - hardware has seemingly gotten out ahead of software that most folks use - watching YouTube, listening to music, playing a game or two. There was a time when playing an mp3 or watching a 4k video really taxed all but the nicest systems. Hardware fixed that problem, like it very well could this one.

1) Another OpenAI cofounder (Brockman) gave Trump’s superPAC the largest ever individual donation of $25m.

2) Trump’s son in law (Kushner) has most of his net worth wrapped up in OpenAI.

A representative idea: if you are the one to kill a deer to eat, you get a little bit of each cut - rib, loin, filet, heart, etc. When was the last time most people ate a filet mignon?

And if you gather food like berries and fruits - you (at least sometimes) get to eat foods ripened that day in the field. How many today get that luxury?

And if one of the things that provides joy to humans is to prepare their family’s food - many folks today would be disqualified.

What about the heterogeneity of the original cells?

Yep - cells would die. ...UNTIL they accrue enough dna damage to accidentally either:

- create a new way to generate thymidine

- fall into a proliferation strategy that no longer needs thymidine

Human cells did the same thing and created checkpoints to preclude malignant growth. There are a number of checkpoints already employed in your own bodies. But if you accrue enough DNA damage, you can get around each of those checkpoints (and get cancer):

- IF too much DNA damage, then die

- IF divided too many times, then die

- IF committed to die, actually die

But if a cell collects enough damage, it can get around ALL of the checkpoints. And evolution has shown us that there is no perfect watcher of the watchmen. Still pretty cool to create a new checkpoint this way.