theophrastus

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Comment · 5 months ago

After spending an entire career doing 'by hand' (and a helluva lot of molecular orbital calculations) on the problem this post is about, i've got to tersely weigh in with: there's (still) not enough available data given the size of protein 'phase space' to hope for a proper covering with one's trained up linear algebra model. Or typed another way: you've got to include at some stage some physical modeling parameters, like molecular orbitals [1], otherwise the 'response curve' will only optimize if one gets quite lucky, (which is actually unlucky as then you'll delude yourself into thinking it's a generally applicable, which it isn't). For instance, swap in a carboxylic acid moiety where there was previously an aldehyde, a protein side-chain flips over, and you're in a completely different corner of the energetic 'galaxy'.

[1] e.g. https://proteindf.github.io/

Comment · 7 months ago

Jameco sells one [1]

[1] https://www.jameco.com/z/KIT-EFK-BUNDLE-Jameco-Kitpro-Compon...

Comment · 10 months ago

Had a QuantSci Prof who was fond of asking "Who can name a data collection scenario where the x data has no error?" and then taught Deming regression as a generally preferred analysis [1]

[1] https://en.wikipedia.org/wiki/Deming_regression

Comment · 10 months ago

Merry Christmas!! you gentle nerds you! Peace to us all.

Comment · 1 year ago

What was the source of the oxygen to maintain ethyl alcohol combustion in a sealed WWII torpedo?

Comment · 2 years ago

Curiously the default has audio output off. That is, was the little speaker icon unmuted?

Comment · 2 years ago

Here's from 2014 with some capacity calculations [0]. "ssh private key (900 bytes): 15 feet of tape."

[0] https://heepy.net/index.php/Data_storage_capacity_of_teletyp...

Comment · 2 years ago

Circa 1980, as a hobbyist beekeeper with six hives nearby Seattle, they came down with foul-brood. (It never was certain if it was American Foul-brood or European) Duly reported and the county agent came in, sealed them, and carted them away. For an additional fee (which I paid) they would fumigate them and return just the hive bodies, but none of the frames, (some of which would contain the infected brood). Those were burned. I believe the fumigant at the time was phosphine[1]

[1] https://en.wikipedia.org/wiki/Phosphine

Comment · 2 years ago

Shouldn't this make some initial direct reference to the author: Silvanus P. Thompson[1]?

[1] https://en.wikipedia.org/wiki/Calculus_Made_Easy

Comment · 2 years ago

Additional small molecule pharmaceutical candidates via molecular descriptors

Comment · 2 years ago

Well done: 3d is an option! Always wondered what emergent properties result from simple rules worlds when the dimensionality goes from 2d to 3d.

Comment · 4 years ago

Lately in advertisements there have been a lot of circular QR codes[1]. Which often apparently present data outside of the alignment patterns. Is that merely an artistic device, or is there some standard permitting information extending beyond the square region?

[1] https://www.google.com/search?tbm=isch&q=circular%20qr%20cod...

Comment · 4 years ago

..and curiously, with the little speaker icon 'on', it produces no audio alarm for me, (firefox 103.0.2). Whereas this[1] one produces a quite notable sound.

[1] https://www.online-stopwatch.com/countdown-timer/

Comment · 4 years ago

As more of a story of external impressions, i'm from Seattle and I postdoc'ed in Germany and I got more than my share of the opinion on English from those who could speak English there (damn near 100% at a University). The first problem they had was placing my accent; they couldn't. Finally they concluded that i was some-sort of Canadian (which is pretty accurate). Then they did their own versions of U.S. accents. Almost universally these divided into New York and Texan. Their impression of the states, based on either vacationers or hollywood, confirmed their view that people from the U.S. were either loud with a Texas accent or loud with a New York accent. We decided that it was a natural sampling bias based on the overhearing of the loudness.