thaw13579

People have a variety of intensities of cravings and capacities for self-regulation (with a magnitude that is largely out of their control). Discipline only works for people where the capacity for self-regulation outweighs the intensity of cravings. These cravings are huge though because our food system is engineered to be both extremely calorie rich and appealing. It's hard to blame people when they're surrounded by fast food restaurants on every corner that has been engineering to target what's called the "bliss point" when experiencing their food.

Looking at this a different way, maybe the discipline / self-regulation needs to be applied at the societal (not individual) level, to improve the environment in which we all live?

The issue is that our modern world has engineered our food to be highly energy-dense and incredibly appealing, so the root cause is an evolutionary mismatch with our environment, which has diverged incredibly from early humans.

Personally, I look at GLP-1 agonists as akin to wearing glasses. Some people are just born without the ability to regulate their appetite in accordance with our society, but there is a tool / prosthetic to change that, often that's a lifelong solution.

It's great to be active, but there's more to it than that, namely that our modern world has highly engineered our food to be highly energy-dense and incredibly appealing. So the root cause is an evolutionary mismatch with our environment, which has diverged incredibly from early humans. Expecting an individual to overcome won't generally work, since their brains are simply wired for it. Sure there are some people who can simply choose to ignore the fast food place at every corner and go to the gym via willpower alone, but they are exceptional in their brain's capacity for executive control.

Personally, I look at GLP-1 agonists akin to wearing glasses. Some people are just born without the ability to regulate their appetite in accordance with our society, but there is a tool / prosthetic to change that. That said, it's not one or the other, it's always great to be more active.

Yes, $50 was a rough out-of-pocket estimate, the amortized cost per scan for operation alone is probably on the order of hundreds of dollars per scan, assuming high utilization.

One funny thing about MRIs is the magnet is always on, so there could be some clever ways to reduce costs running them after hours.

From what I know, seems like a mix of medical price fixing by the gov't, adoption of lower cost hardware, and universal healthcare. There's apparently less bureaucracy, perhaps because there is no need for negotiation at every step of the process?

Yes totally, and ultrasound already does wonders in that regard. It's a good strategy to focus on the specific use cases that match the strengths of the tech. I think MRI will be useful in validating and mapping out those cases.

Yes, that is a economic & public health policy problem that really needs to be solved. We can look to Japan as example of what's possible, they have invested in nearly twice the number of scanners per capita of Canada, and they can get same-day MRIs for $50, roughly speaking.

Cool work and proof of concept, and very excited to see where this goes. However, I do think there is enough exaggeration and missing information here that it warrants some critical appraisal. What's really missing is a comparison and validation with any existing medical imaging tech. Whole brain, contrast-free neurovascular imaging is essentially solved with MRI, why not run a scan and compare? Ultrasound is of course portable and less expensive, but MRIs are actually widely available in most cities at reasonable cost for medical workflows, and low-field brain MRI is addressing the portability and cost issues to some extent. I guess they are pitching this as a wearable "telepathy" device, which I think appropriately differentiates their product, but of course, this wording also invokes a framing that "you won't / don't need to know how it works," which invites skepticism and a higher bar for validation in my view.

That's literally treating people as means to an end, when it's not clear if the "end" even required sacrificing young people's lives. In the grand scheme of things, why not spend an extra year to build at a pace that doesn't burn people out? If you look at the careers of the people who subsequently left, by Sandy's account, they went on to to run their own great game studios, so it's not clear that a grind was necessary.

They haven't shared enough to say anything concrete, but one important detail is that this system doesn't have many of the benefits usually found in ultrasound (portable, cheap, simple). From what they've shared, it's a large water bath that patients need to be submerged in with a large array of US sensors with high costs in data and reconstruction compute. It might have lower upfront cost, but otherwise, I personally don't see the advantages yet. A typical MRI can be done is under 30 minutes in street clothes, and personally I'd rather not deal with the logistics of a water bath...

To be honest, this one could just as well be a sloppy bibliography.

The core issue is that X is now a tool for creating and virally distributing these images anonymously to a large audience, often targeting the specific individuals featured in the images. For example, to any post with a picture, any user can simply reply "@grok take off their clothes and make them do something degrading", and the response is then generated by X and posted in the same thread. That is an entirely different kind of tool from an open-weight model.

The LLM itself is more akin to a gun available in a store in the "gun is a tool" argument (reasonable arguments on both side in my opinion); however, this situation more like a gun manufacturer creating a program to mass distribute free pistols to a masked crowd, with predictable consequences. I'd say the person running that program was either negligent or intentionally promoting havoc to the point where it should be investigated and regulated.

Those were most likely from a multi-line list that was converted to a single line when the comment was processed on submission.