stephenitis

Psychedelic trips are taxing on the body and I think I agree with the hypothesis nutrients are underestimated in supporting a healthy mind in these states, from personal experience.

Comment · 3 months ago

I agree with the sentiment entirely. I moved from the Bay Area to the DC Maryland Virginia area. the viewpoints out here have been strangely stuck on opinion pieces written during the gpt-3 era. Same goes for electric vehicles.

It’s slowly changing for some of the holdouts out here given how immediately useful certain personal and business use cases can be.

Comment · 5 months ago

You seed the gut with nutrients. having lots of fiber and a varied diet increases the number of species that an adult has which is between a couple hundred to a thousand or so. Our guts are generally dominated by a bunch of beneficial bacteria.

which for many is not the case for a variety of social economic or behavioral reasons. Add in with explosions of bacterial populations due to alcohol or sugar and you can see how we can change our gut biome drastically from week to week.

Comment · 8 months ago

wow, i didn’t know this existed until now. thanks!

Comment · 9 months ago

that said, if i floss, occasional use mouth wash, or drink a alcoholic beverage will this bomb the micro biome in my mouth making a one time dose magic cure a expensive maintenance cost?

Wouldn’t it be better to have a probiotic toothpaste?

Comment · 9 months ago

my next question would be what is the effect of mutacin-1140 on the gut microbiome.

I looked up mutacin—1140, found this 2018 study looking at the effect on staph and possibly positive persistence in the gut.

https://pmc.ncbi.nlm.nih.gov/articles/PMC6256755/

> “Nisin and mutacin 1140 have potent activities (nanomolar or submicromolar activity) against well-known Gram-positive pathogens, including Staphylococcus aureus and Streptococcus pneumoniae. Nisin has been used as a food preservative for more than 50 years without inducing significant resistance”

> “ Despite the short half-life of mutacin 1140 in blood, analogs of mutacin 1140 were demonstrated to have increased gastric stability and were effective in treating a Clostridium difficile infection in hamsters “

this very interesting to me.

we fought off a extreme overgrowth of staph aureus with a regiment of probiotics and bacillus subtillis (a bacterium found in dirt that is known to disrupt quorum of bacteria that create biofilms.

biofilms are a huge reason to floss and brush our teeth, it’s like a slime that protects and nourishes the bad bacteria on our teeth.

this bit from the sparse wikipedia was interesting. “Mutacin 1140 belongs to the epidermin subset of type Al lantibiotics.”

are there other bacterium in our oral/gut that produce these kind of compounds?

Comment · 9 months ago

doesn’t that bacteria strain need to colonize your mouth somehow? how would that happen if we are constantly exposing our mouths to various foods, liquids, and dental products?

citing the discovery from 1987? synthesis of the strain in 2002, and then moving onto the product recommendation without going into the mechanisms that allow such a bacteria to persist after just one magical application feels very snake oil to me.

we can use metagenomics to test the rna and dna of our oral microbiome. (testing is somewhere around $200-400 a swab currently)

show me the data even with a low N value of test subjects that give a oral microbiome analysis weeks, months, and years out after just 1 application and you’ll have my curiosity, maybe my money.

also give recommendations about if and what habits and behaviors would wreck this expensive bacterium’s viability in our mouths.

* this is coming from a father whose tested their child’s poop with inhale every 4 weeks or so several times to debug a believed to be rare (but science doesn’t truly know) staphylococcus aureus & eczema issue

i’m skeptical but i’ll stay open minded

found this explanation on why they went the probiotic route rather than seek FDA approval. from their subreddit that https://x.com/yishan/status/1780131552615420189

> 1. Move forward with manufacturing and distributing this as a probiotic supplement > 2. Once a critical mass of biohackers and early adopters take this treatment, other third-party research can get involved

https://www.reddit.com/r/lanternbioworks/s/01haEdviDz

Comment · 9 months ago

I’m with you, repeating it is like low effort copy pasta when they should’ve put effort into backing up that claim.

Comment · 10 months ago

Regular brushing at least once weekly. Husky owner here. 2 roombas 2 dysons

Comment · 10 months ago

Genius! Why I didn’t think of this!