soudiere

Many reasons, that's a different discussion.

Note that you've gone from this statement, to acknowledging that they are regularly prescribed.

> Imagining a doctor writing a script for meth is pretty amusing, and maybe if that’s not a cool enough drug, they can hand out some crack or something.

That statement is true of all amphetamines.

Look, this is what I'm driving at, you appear to have some illusions that methamphetamine is significantly different than other amphetamines, or has some higher toxicity profile, more addictive, IDK I'm trying to get you to tell me your biases.

At that point, we can go look at the clinical literature and see what the evidence is.

You most likely did far more than 50mg of methamphetamine.

I just weighed a couple 20mg orange adderall pills, they're each around 0.2-0.3 grams (my scale is only accurate to 0.1g)

Why is it amusing? Because you think it has no therapeutic value?

Serotonegic? What does that even mean?

For a given quantity, eg 1mg, of methylamphetamine vs d-amphetamine, the meth will release more serotonin?

The worst discussions we have on Hacker News are around healthcare and medicine.

For some reason the community refuses to apply a high of research and rigor to this topic, as if it's lesser than the non-sense we call computer science.

This entire debate is comical, the medical community's approach has been, by it's own admission, to throw various stimulants at ADHD. Methylphenidate, L-Amphetamine, D-Amphetamine, Lisdexamfetamine, etc.

By in large, everyone on this thread is pretending like there is a treasure trove of research demonstrating the superiority of Adderall (a racemic mixture of L & D amphetamine) to Methylamphetamine.

And that's just not true at all, there is a paucity of research on the subject. Meth = Bad because of the Germans and street drug users (who smoke an uncontrolled amount).

DEA isn't the issue here.

The Justice Department brought the lawsuit against Purdue Pharma, and distributors are scared.

Higher potency, longer duration of action.

If your goal was to get inebriated (drinking), would everclear be more effective than vodka?

Why does it blow your mind?

People who do a lot of meth tend to smoke it.

Method of administration affects the time delay for euphoria. Smoke > Shooting > Eating.

People who do a lot of meth (or drugs outside of a prescription) tend to do as much as they can purchase and/or tolerate.

When you see someone who has a doctor (dealer) that gives them as much adderall as they want, illusions of differences between the two drugs rapidly fade. I'm talking about 100+mg a day, I've seen it happen, still have 50mg adderall pills from the person in the story.

Bingo

Yeah, this guy doesn't know what he's talking about.

If we just discussed this as d-amphetamine, l-amphetamine & methyl-amphetamine, the issue of interchangeability would be less confusing.

Adderally XR formulations are still a minority of prescriptions.

Talking about methamphetamine as a different molecule is not helpful, as Adderall itself is not a single molecule.

Which I suspect you know, as you mention different enantiomers of thalidomide. However you don't point out that adderall itself is a 3:1 racemic mixture of l and d amphetamine.

The real discussion here is the receptor binding affinity of the various targets of the drugs, and how they compare.