simonmesmith
Joined 4 years ago
Joined 4 years ago
“Almost all scenarios that limit warming to 1.5°C or 2°C require novel CDR.”
“Virtually all current CDR (99.9% or 2 GtCO₂ per year) comes from conventional management of land, primarily via afforestation and reforestation.
Only a tiny fraction (0.1% or 0.002 GtCO₂ per year) results from novel CDR methods which involve storing captured carbon in the lithosphere, ocean or products.”
So, long way to go if we think this is what we need.
Currently, the US labor force participation rate for those 15+ is at about the same level as it was in 1977 and down from its peak in about 1997, after which it has been on a steady drop with a small uptick in 2019 and again last year. See this chart: https://data.worldbank.org/indicator/SL.TLF.CACT.NE.ZS?locat...
I’m not an expert at all but I just find that the unemployment rate in isolation is hard to interpret unless you also look at labor force participation. An unemployment rate of X% in 2023 is different from X% in 1997 in terms of the percentage of the population actually working.
Also, I was curious about whether this would also work with images. So I chopped an image of a bird (a night heron) on a boat in my own collection (so, not in GPT-4's training data) into squares and randomly rearranged them, then tried to get ChatGPT-4 to interpret it. It doesn't work. I got this:
--- CHATGPT RESPONSE:
The image you've uploaded appears to be a composite of several smaller images that are cut and arranged in a grid-like pattern. This collage-like arrangement makes it difficult to discern a clear, singular subject. However, I can identify fragments of what seems to be a bird—possibly a magpie or some type of corvid—due to the black and white plumage. There are also elements that look like parts of a silver car, like a side mirror, and segments of wooden structures that could be parts of a bench or a deck.
The way the images are scrambled resembles a puzzle, where each piece needs to be placed correctly to form a coherent whole. This type of image could be used as a challenge to reconstruct the original picture, requiring the viewer to mentally rotate and arrange the pieces.
---
Maybe a different approach to scrambling an image would work.
I think a better explanation is “the halo effect.” Businesses have success, even if for a limited time, and using limited definitions (e.g. VC valuation), and people tell stories about why they’re successful that put leadership, strategy, culture, and so forth, front and centre, when it could have been dumb luck or a low interest rate environment or other factors totally unrelated to leadership, strategy, and culture.
A book that really opened my eyes to this was The Halo Effect: https://www.goodreads.com/en/book/show/136181
PS: I enjoyed the book.
Those ingredients looked familiar to me from work I’ve done with skin health products. They’re cosmetic product ingredients. A quick ChatGPT check:
- Salicylic acid is a beta-hydroxy acid commonly used in acne treatments and exfoliating products. It penetrates oil glands to unclog pores and has anti-inflammatory properties.
- Glycolic acid is an alpha-hydroxy acid mainly used for skin exfoliation and anti-aging. It helps remove dead skin cells and can improve the appearance of fine lines.
- Tretinoin is a prescription-strength retinoid used for treating acne and signs of aging. It promotes skin cell turnover and boosts collagen production.
So, if this $0.50 soap bar gets to market, I assume it will quickly be snapped up by people looking to generally keep their skin young and healthy, because that’s a hell of a lot cheaper than other products containing those ingredients.
For example, if you ask an LLM to create a graph of all proteins related to X disease, and show how they interact, it will oblige. (You can try this yourself easily in the OpenAI playground. Just ask it to send you back a list like X -> Y -> Z or whatever. Or an array of source/target/relation triplets.)
The challenge is that what you get will be very dependent on how you phrase your request. So you’ll never know if you’re getting a “complete” graph or just the most probable graph for the request you made. If you’re an expert in the domain, you’ll know, but if you’re an expert you might not need the graph in the first place.
The target for the two major monkey studies (that I know of) to date was a 30% reduction.
The results of those studies, which had conflicting results, showed that even at that degree of calorie restriction, dietary quality was likely more important than calorie restriction for health and longevity. Peter Attia summarizes this well here: https://peterattiamd.com/calorie-restriction-part-iia-monkey...
My takeaway from all of this is Michael Pollan’s mantra: “eat food, not too much, mostly plants.”
I was able to get the prescription from my doctor by presenting evidence and the rationale and design for the TAME trial.
He was comfortable with this due to the strong safety history of the drug. Insurance covers it (though it’s very cheap anyway) and I pay nothing out of pocket. I live in Canada and also have private insurance through work.
I had some gastrointestinal issues initially, but they weren’t serious, and my body adapted fairly quickly as they want away. I tried taking metformin while doing an 18:6 intermittent fast and gastrointestinal symptoms returned, so I won’t be doing that again.
There is some debate about the benefits and risks of metformin, but so far I haven’t experienced negative side effects of concern to me. I’ve had various tests over the past five years—blood, urine, body composition, etc.
As for the TAME trial, while there have been positive developments, I’m now doubtful it will ever actually run. I have a prediction market on Manifold right now that shows a 25% chance it will be listed on clinicaltrials.gov by the end of the year.
I’m not trying to promote the market (the main benefit to me is more market participants hopefully means better forecasting), but if anyone’s interested, it’s here: https://manifold.markets/SimonSmith/will-the-targeting-aging...
* Is that the right chunk size? How much of a chunk might contain the relevant information? Is it better for your use case to chunk by sentence? I've done RAG with document chunks, sentences, and triplets (source -> relation -> target). How you chunk can have a big impact.
* One approach that I've seen work very well is (1) first, use keyword or entity search to limit results, then (2) use semantic similarity to the query to rank those results. This is how, for example, they do it at LitSense for sentences from scientific papers: https://www.ncbi.nlm.nih.gov/research/litsense/. Paper here: https://academic.oup.com/nar/article/47/W1/W594/5479473.
* You still need metadata. For example, if a user asks for something like "show me new information about X," the concept of "new" won't get embedded in the text. You'll need to convert that to some kind of date search. This is where doing RAG with something like OpenAI function calls can be great. It can see "new" and use that to pass a date to a date filter.
* I've found some embeddings can be frustrating because they conflate things that can even be opposites. For example, "increase" and "decrease" might show up as similar because they both get mapped into the space for "direction." This probably isn't an issue with better (I assume higher dimensional) embeddings, but it can be problematic with some embeddings.
* You might need specialized domain embeddings for a very specific domain. For example, law, finance, biology, and so forth. Certain words or concepts that are very specific to a domain might not be properly captured in a general embedding space. A "knockout" means something very different in sports, when talking about an attractive person, or in biology when it refers to genetic manipulation.
When I was a child and teenager I loved science fiction. When I became an adult I shunned fiction as a waste of time and read only nonfiction books. Then I started to find that most nonfiction books could be summarized in a blog post or Wikipedia entry, regurgitated well established ideas, or spewed unfounded bullshit. I’ve since flipped my perspective again. I think good fiction is worth reading at book length while most nonfiction is better consumed in blog posts, articles, journal papers, or via a ChatGPT tutoring session.
I will highlight one consistent exception. I love every book I’ve read by Yuval Noah Harari.