rheng

Joined 16 years ago

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Jun 17

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While the Lenire device may appear similar at first glance because it uses comparable stimulation protocols, I believe Susan Shore’s device is superior. Shore’s approach targets the root neurological cause of tinnitus and aims for measurable reductions in loudness, whereas Lenire primarily focuses on reducing how bothersome the ringing feels. Shore’s research also follows a more first‑principles, neuroscience‑driven path—from basic lab work to carefully controlled clinical trials. Additionally, her studies were more rigorous, incorporating proper control groups, something the Lenire trials lacked.

Comment · 7 months ago

I also have been suffering from tinnitus a little over a year now. It definitely has impacted my sleep, especially my mornings. It's the first thing I think about when I wake up.

I've been following the work of Auricle Inc., a company commercializing decades of neuroscience research out of Dr. Susan Shore's lab at the University of Michigan. (Full disclosure: I have spoken to their CEO about potentially helping with their funding, although my primary concern is getting their product to the public).

Instead of just masking the sound, their device targets the root cause using bimodal neuromodulation. It pairs specific audio tones with mild electrical pulses to the jaw/neck to desynchronize hyperactive neurons in the dorsal cochlear nucleus.

Here are the two papers that cover the underlying science, and go over the efficacy:

The foundational mechanism and Phase 1 trial showing how it induces long-term depression (LTD) in the brain circuitry: https://www.science.org/doi/10.1126/scitranslmed.aal3175

The Phase 2 double-blind, randomized clinical trial results showing significant reductions in tinnitus loudness and burden: https://jamanetwork.com/journals/jamanetworkopen/fullarticle...

Comment · 11 years ago

That explains a lot. Thank you!

Comment · 11 years ago

Fantastic work! It is exciting to see a project like this take off. I'm trying to dive in right now, and I noticed something interesting. Pardon my ignorance, but can you explain what this is?

module.exports = { route, routes };

I got an error when I tried to do this:

var a = {1, 2};

What is it setting in that case, since there is no concept of tuples in javascript? It doesn't seem to be an array, dictionary, or function. Appreciate any advice!