Recent submissions

Comment · 10 months ago
It’s also the metabolic changes in pH. CO2 is a proxy for ph as carbon dioxide acidifies the blood as it dissolves.
Comment · 1 year ago
Comment · 2 years ago
Starship (including the Super Heavy) weighs about 10x as much as the Starliner (including the Atlas V)
Comment · 3 years ago
Do you have any evidence to support any of these claims
Comment · 3 years ago
I would counter that by pointing out that if your aim is to achieve a certain degree of bioavailability of TCH, you'd have to smoke a larger quantity of a lower-potency product, thus exposing yourself to more of the combustion by-products than necessary.
Comment · 3 years ago
Yes thank you. Midnight brain fart. It was Farxiga & Jardiance I was thinking of
Comment · 3 years ago
> 2. Glucose is transported in intestines via a glucose-sodium antiporter protein. Maybe we can find a drug that blocks this and you can eat as much sugar as you want! (Turns out you’ll have uncontrolled diarrhea if you do).

It's very cool! It's the SGLT protein. It's actually a sodium-glucose co-transporter and is why gatorade is so effective! It's the perfect mix of salt, sugar, and water to take advantage of that very protein (where salt goes, water follows).

And yes there is a drug that targets these - it's the SGLT inhibitors and they're very in vogue right now. Ozempic and Mounjaro are the two big ones in the news right now. They act on the SGLT I (found only in the kidney) so that you urinate more sugar. They don't act on the SGLT 2 (only found in the gut) but other medications in that class act on both.

But congratulations and alas! You nearly invented gatorade and a multi-billion dollar diabetes and weight-loss drug. Hardly bone-headed ideas.

Comment · 5 years ago
Deep vein thromboses are real. It is very much recommended particularly on long haul flights
Comment · 5 years ago
>But teams behave in an infinite combination of size, members, companies, and time

Slightly off topic, but I realize this is a subject I'd be interested in reading more about. Would be interested in suggestions in the same vein as Creativity, Inc. by Edwin Catmull?

Comment · 5 years ago
I think they were trying to make a joke and meant “redundant” instead of “oxymoron”
Comment · 5 years ago
Unfortunately, it isn’t outlier behavior
Comment · 5 years ago
Comment · 5 years ago
Funny, I misread the comment the exact same way. He was not suggesting that “ok” is derived from “poppycock”
Comment · 6 years ago
They didn’t say all side effects were attributable to nocebo effects.

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