pcorsaro

I've been running a video game collection site for years. The number one request I get from people is to build an app. I've worked so hard on making the mobile version of the site to be just as functional as the desktop version, and I don't really understand why people want an app over just using the web version. I sometimes wonder if I should just do it to see if I'm missing out on market share, but I don't really want to have to maintain two different user interfaces.

You didn't actually click and read anything. Hank's page is saying exactly what the article you linked is saying. CRC is on the rise in young people. I'm not sure why the moderators changed the title of this post. It should be "Something is Going on with Colorectal Cancer."

I sell stuff to a lot of restaurants. Most of the people that open a second location end up making less money or end up closing everything after they just get run into the ground. Then again, some people do it successfully and make way more money. It just depends on so many things.

I'm not the OP, but I had a CGM several times through Levels. I can tell you that the major spikes (glucose over 200 after sitting between 80-90) really made me feel like shit. The 2 times I can remember it getting that high were when I had too much sushi, and a huge bowl with white rice from Chipotle. Brown rice never seemed to spike me nearly as bad, especially if paired with something high in fiber like black/brown beans. From a long term health perspective, I have no idea if it's a problem or not. I didn't like how bigger spikes felt, so there's probably something to it being bad for you long term. Obviously the more often you spike as a "healthy" person, the less sensitive your body is to insulin. Staying even on my glucose levels is always where I felt the best.

> You don't get to just 'decide' if your fledgling business is a potential unicorn or will just be a lifestyle SaaS business. It's a product of your idea/technology, the size of the market, competitive pressures, and your early traction.

Sure you do. Of course there are types of businesses that only succeed if they're a unicorn, but for the most part, you can decide how much business you want to do. I know we're talking about software, but I deal with lots of restaurants in my life. Say you start a restaurant, and after the initial opening craziness, you see that's it's a sustainable business with lots of loyal customers that like your food. There are people who are going to tell you to open another location, to franchise it out. You'll need investors to do that. It may or may not make you more money. You might think your product has the potential to be the next big chain. You also get the choice whether you want to do that or not.

If you have a good product that people want to pay for, you more than likely will have the choice to decide whether you want to scale the business up larger.

Lots of people have responded to this with similar strategies to what we used. Keep in mind, my wife was 35 when she went through this. We had a 1 and a half year old, she was breastfeeding and was in decent shape overall. For the first few treatments, she was able to fast for a couple of days before. She did a fairly strict keto diet for a few treatments as well, with her ketone levels being 1.5 millimolar or higher. She did take metformin for a little while, although she quit taking it after a while because she just forgot and was overwhelmed.

All that being said, she pretty much abandoned all of the additional about halfway through her treatments. She had to have half her liver resected, and she had a HIPEC procedure at the same time. When they did the final biopsies on her metastases in her liver, it was 100% dead. She's now been NED (no evidence of disease) for a few years now. I don't have delusions that it will never come back, but I can hope.

I don't know if anything she did helped the chemo do it's job. It's not exactly something you can A/B test. I think it's possible, but I also think her being so young and in good shape to start with made the biggest difference.

The debate about Vitamin C in the cancer world is never ending. My wife had stage IV colon cancer a few years ago, and we went through tons and tons of research to try and find things to supplement her chemotherapy. A lot of the "alternative" medicine people suggest doing extremely high dose Vitamin C intravenously because supposedly at higher doses, it becomes oxidative and generates free radicals in the blood stream which can kill a lot tumor types. Her oncologist didn't like the idea because there is also lots of research that says it spurs growth in tumors. He said that Vitamin C gets studied so much because it's cheap to get, but it's never really produced any meaningful results. There was a study he liked about taking extremely high doses of Vitamin D, but I can't really remember why.

There are some sites that I am actually signed up for their newsletter, I'll click a link in the newsletter to read the article on the site, and then I still get a popup on the site to signup for the newsletter. Most newsletter links have referral URL parameters. I don't know why they can't detect that I came from a newsletter click and just not show me the popup. I understand it could be "abused" or if the link was forwarded from someone you might want to try and capture new subscribers, but I feel like that's a small enough percentage that it would be better to make the experience less annoying for your regulars.

Disruptive? It's a bog standard savings account with Apple's terrible Wallet interface. It's convenient if you have and actually use an Apple Card I guess. I personally only use my Apple card for Apple purchases because that's the only place you actually get a good rate, and I just use other cards with better cash back on everything else.

I don't think we're in a recession. At least not yet. I think your point about salary expectations is kind of interesting though. In my industry (restaurant disposables), we're going through a big price "reset" right now. Almost all of our pricing is trending towards where it was before everything started going crazy in 2021. Maybe tech salaries are heading the same way?

Just index funds for the most part. I don't attempt to time the market really. I assume you're implying that if I had known things were going to slow down I should have made a fortune trading stocks. I'm not saying anyone had a crystal ball for when the market was going to slow down. I think that's kind of a fools errand for most retail investors. All I'm saying is these companies keep making statements saying that growth didn't meet expectations. It just feels really disingenuous to me is all I'm saying.

Every one of these companies doing layoffs says something like what's in this update: "user and revenue growth has not kept pace with our expectations." I find it really hard to believe that all of these companies assumed that growth during Covid was sustainable and would just continue into eternity. I have a small restaurant supply business. Our revenue was up almost 50% above our best year ever. We knew there was no way it was going to last forever. All of these companies just sound so disingenuous when they say their growth didn't keep up with their expectations. They knew this day would eventually have to come, they just don't want to come out and say that.

Houses aren't selling in hours anymore, sure. A ton in my area are sitting for days, but prices haven't come down all that much.

I don’t doubt your statement about the artificial sweeteners, but how in the hell are you getting to 9mmol/l of ketones? I’ve seen levels around 5 after several days of fasting. You’d have to be ingesting ketone esters or something to get to 9.

I'll have to check it out. I did not know that.