medimikka
Joined 4 years ago
Joined 4 years ago
It's 2026, social media has to be flashy, go right to the gut. We've become dulled to the realities of the world, so harder hitting content is the only thing getting a reaction. And accounts/sites like this one provide that hard hitting gut punch, if need be by inventing a new narrative.
One can hold both thoughts at the same time and still understand, why a page like this causes concern.
I am not a fan of domain name cessation or any kind of blocking access to data, but I'd imagine NameCheap did have a particularly high amount of complaints and legal inquiries (one comes to mind, where the site posted pictures of a Hamas hostage in a tunnel as "Israel starves teacher and forces him to dig his own grave" that is in litigation), that at some point beg the question if $5/year is worth it.
There's nothing wrong with having LGBTQIA+ flags in your app to highlight marginalized groups. But to respond to a plea for extension of that list with "fuck you, Nazi Transphobe Sexist Scum" isn't the way to go.
The VAST majority of my LGBTQIA+ friends in health care agree. Your candle won't burn brighter if you blow out other candles. Adding more colors, adding more flags, adding more recognition, does not diminish the recognition of the original marginalized groups. If anything, it creates understanding, community, personhood, and normalizes LGBTQIA+ as not an outlier but one in a scary number of identities and groups that are being mistreated.
Which says a lot more about them than it says about Brave.
Any ED resident on their first week on the job should know how to diagnose sepsis: Temp >38°C (100.4°F) or <36°C (96.8°F), Heart rate >90, Respiratory rate >20 or PaCO₂ <32 mm Hg, WBC >12,000/mm³, <4,000/mm³, or >10% bands, Infection (suspected or present).
Double down on the blood work, take liquor, empirically give antibiotics (less and less useful, given resistances), drop temperature (paracetamol), add fluids (drops heart rate, ups blood pressure), wait for labs.
It's not hard, and I am so very sorry someone with sepsis signs was sent home. Sepsis is also a fast bastard. Meaning, from pathogen entering the blood stream to organ damage and conclusively death can be less than half an hour. That's the ones we can't catch. The guy with the ulcer, the person who injects things, the girl who didn't see a dentist about her developing abscess, the man who stopped his HIV meds... that's the ones I didn't in the past three weeks. I got them too late, or didn't see them until the ambulance unloaded a dead person.
Sepsis is a bitch. A total and utter bad player, something we drill into every resident from day one. Sometimes Mrs. Goodforall comes in with a light chest tightness and leaves on a hearse, sometimes Mr. Bluebird presents with nausea and crashes into a full on septic shock minutes later. Any one of those I can prevent, I will. I am, however, not God. Just a ED jockey with an infectious disease background. I'm probably the best hope my patients have, which isn't much, but it's something.
Some gets to where it needs to be, the rest gunks up the engine on the outside and in places it shouldn't be.
Almost any drug acting on 5HT (fk acts on 2C), acts on other receptors as well. Fk acts on α1, M1-4, and many more, it's not very selective. A venerable bucket of oil, indeed. This is, what also causes Long-QT, feeding disorders, diarrhea, shorter pregnancies, dry mouth, sexual dysfunction, and more.
Sure, dropping such a bucket of oil can also, via inflammatory pathways, elicit IL-10 activation and, more importantly, act against hypertriglyceridemia. But that should not be sold as a solution to a problem. Again, to stay with contrived comparisons, if I load the boot of a car with C4, I am sure that some parts of the car will reach more than the car's stated maximum speed. But that's not a desirabe outcome.
As a last ditch, I'd consider it. But "preventatively" as suggested... that's a far, far, reach.
Matt, literally (he turned 21 then), came of age in the 2004-2006 Silicon Valley climate of the post-Bubble "Trümmerfrauen" (https://en.wikipedia.org/wiki/Tr%C3%BCmmerfrau) movements that brought us things such as DHH and Rails, Matt and WordPress, Andreessen being himself, and others, all of which are now considered "problematic."
I don't think Matt has changed. The climate these projects operate in, has. To some it's an eggshell walk, to others a game of signaling the right virtues while acting against them in secret, and to some a chance to achieve relevancy or dominance. And for all of them, there's a day of reckoning. 2005s proclivities have no similarities to 2025 dogma, and why should they. Neither did 2005 have any with 1985. Feel old, yet?
Matt's Matt. That Matt was what was needed to kick a floundering piece of software (P2) into the kind of trajectory that helped transform it into the absolute unit of a social and communications portfolio, Automattic is today.
That kind of Matt is a dinosaur in 2025. As were 1985 coders and founders in 2005. Heck, 2005 didn't look too kindly upon 1999 Silicon Valley mindsets.
I guess Matt's "problem" is not, that he has changed. Matt's difficulty is, that he hasn't, and that 2025 is nothing like 2005. And, like DHH or Andreessen or Brendan Eich back in 2014, that can ... hurt. I'm too old to care, but I'd presume today's "golden child" will be a very problematic person in 2045, unless they learn to change or hide behind signals.
Even more, I can have split logic based on window size, window titles that show me who also checked out a file while I am inside an editor, even per-window color and font schemes.
All apps should use something like Lua for their config.
Others have tried to solve the intersection of new discoveries and daily reading workflows, but only Arc seems to present the latter in a way that does not get in the way of the former and does not require N keypresses to get there.
Sidebar plus floating URL bar means much less window chrome, which is (especially for people like me who haven't owned a monitor or a desktop PC for a decade) a welcome freeing experience that maximizes screen estate.
Having a baked in tracker stripper for a one-keypress URL copy is, especially for people like me who copy dozens of URL daily, a boon. No other browser seems to think, that this is something that is needed. And most users seem to have arranged themselves with two keystrokes to highlight the URL bar and copying the contents, followed by dozens of deletes to remove trackers.
Sure, it's small stuff and easily waved off, but if none of the other browsers wants to break with the Netscape early days paradigms, Arc it is[1].
[1] Zen Browser tries, but then, that Mozilla underpinning often sabotages the experience.
To correct this, though. You can buy all those in the US as well. Holter and FirstBeat are selling clinically validated and FDA approved mutli-lead ECG, Derxcom is selling an over the counter CGM, as is Abbott with the Libre 2, and a Chinese company has recently joined there, too.
Low calorie meal replacements are all over the store, too.
If you're a member of this orthorexia/orthovivia crowd, you have the same access to tools as you do in the EU, often more so.
Luckily, there's xDrip4iOS and xDrip++, not to mention Suggah and others, who will happily do the alarming part for you. Not to mention, that to many of us T1D, the CGM is just a secondary data point for our loop, which has a CGM already built in.
This life and death situation demands a certain decorum. Among others, to rise above the "hi I am coolwulf" stage of interpersonal interactions.
Let me go to a different topic in the same ballpark: imagine you had to build your SARS-CoV-2 response plan based on either a panel of women and men whose name and credentials you are privy to, or a single individual with a blog calling themselves "y0m0mm4" - which one would you, reasonably, choose to consider? Yes, the single individual may have, by chance or skill, happened upon the perfect plan. And, yes, the panel of experts may be completely wrong. But in medicine we call this a Zebra, a very rare event that, in a discipline of probabilistic empiricism, should not initially be considered.
I don't doubt, that all the above might come together to greatly improve treatment decisions. In fact, I know it, because as I said repeatedly, Bruker, Siemens, Tally, and others work on those solutions as well, and they are being used. Initially only in secondary verification, but with three FDA approvals expected this quarter, there might be much more coming.
I just don't think a pseudonymous account on Hacker News is the place to farm something that, not unlike many other medical interventions, has a massive potential of harm. As a somewhat related side note: the US was spared the horrors of thalidomide, because a single woman at the FDA (Frances Oldham Kelsey) refused to certify a medication that did not list the names of the inventors. When she did not get answers to her questions, largely because Grünenthal refused to let her speak to the drug's developers, she refused certification. In medicine names mean something, and if it's just the ability to verify background claims.
Yes, I know. I worked in Ghana. And, know what? Unless you're running a $5m/month Cyberknife or similar, you don't do those dual modality approaches. Most, literally all except five or six research hospitals in the US and EU, treatments still work (very well) with lead marker lines on patients. We image, we look at the image we stage, we localize, we take out a tape measure, we draw. It might sound archaic, but it works extremely well, especially in places like Ghana.
I'd seriously love to see "coolwolf"s experience in developing country cancer treatments. I mean, in developing countries we deal 95% with cervix, breast, liver and prostate. Neither are hard to image and localize/stage. In the case of higher stages, exploratory imaging is also done, but those lesions aren't of initially surgical or radioherapeutic concern. Those who are, can be localized by eye only. And that's the ones, that software outlines.