mapkkk

While this isn't what you asked, there are plenty of used older generation LTO drives to be had for cheap on ebay. A few years back I got an HP LTO-5 drive for $85.

Plus, having your backups on used hardware _instills_ the importance of proper backup hygiene like nothing else!

Not OP, but I've been trying out Sol 6.1 medium with hermes agent, and I have not been able to match usage costs to what I've been getting with glm 5.3 flash high.

Really don't know why, since I've offloaded thinking to the LLMs in this area of my life. Though even at medium, 6.1-Sol is noticeably better at most tasks I throw at it.

I would argue that fent became an issue only after the oxycontin et al. peddling was slowly curtailed; together with fent precursors becoming absurdly cheap to procure and process, compared to other opiates. Users originally hooked on the pills needed a replacement, and as suddenly the chemistry got much cheaper, everyone switched to fent. The physical volume of illicit substance you need to smuggle is also lower with fentanyl, so I'm sure that would have played into this trend as well.

If you want to find where to point the finger to, the systems that let prescription opiates be prescribed with such reckless abandon is a good superficial target. Getting political here - if you want to find the very root cause of all this, I would present the institutions that prevent the implementation or otherwise erode preexisting social safety-nets as the culpable party.

This is what I immediately thought of as well, I'm just grateful you remembered the name of the project.

An absolute blast from the past, thank you for unlocking the memories of me reading these cool projects way back when!

These are the same CGM technologies (Dexcom = Stelo and Lingo = Libre), just aimed at the over the counter "health and fitness" market.

This is not verified info, but I would assume these are either A) the exact same device, just with different marketing B) "binned" production runs that did not meet the accuracy threshold for clinical/prescribed use, but are otherwise "good enough" for someone looking to healthmaxx.

I would postulate that it's even worse than this, given that default mode network activity is proven to be essential for a healthy mind. This is when engage in useful thinking even when we're not "doing anything".

I think screen activity/tiktok keeps us in some kind of purgatory where we can neither fully engage nor fully disengage.

hell, you could even fedex them your own remote hands a la LTE modem tied to an rpi.. you could do what you need to by the time someone gets around to opening the box

I can second this. Back when I first set up my free tier resources there I confirmed this with a sales rep, PAYG accounts will have immediate access to free tier resources, that limitation is only for trial accounts.

If you "upgrade" your account to PAYG you will not have this limitation. The "no free instances available" issue is only for accounts without a payment method.

I got this confirmed with a salesperson ~2yrs ago when I first set up my free tier on there.

I'll (lightheartedly) come to their defense to say that this is how I and a lot of my peers made it through med school. The wetness of the page indeed unlocked some supressed memories.

I think it's a combination of a ritual and some sort of somewhat-more-elevated engagement (or wishing thereof) with the material. Somewhere between meditative ritual and attention aid. I doubt it helped much, if at all - except for Stabilo; they were the true winners.

There's support for encrypted communication with TPMs, but if I remember correctly this is almost never enabled by default.

I presume you're referring to receptor upregulation in response to the drugs. Bear in mind as you read my comment that this isn't my primary area, and it's been a while since I last studied cell biology and signalling around G-protein coupled receptors. I also have not gone out of my way to read papers about the cell signalling pertaining to these drugs, only papers around clinical outcomes for these class of drugs.

After discontinuation, most patients regain around 60-80% of the weight they've lost with the medication - but this figure is limited to the study duration, so the weight regain might have continued beyond that. A good starting point for dipping your toes into outcomes would be the STEP and SURMOUNT trials, these were the trials they did for marketing approval. (They did multiple rounds of these, I believe STEP4 and SURMOUNT4 specifically had groups that stopped therapy mid-way).

We see this rebound effect with weight loss mediated solely via lifestyle modification as well, however. Still no idea why. Very broadly speaking, only a small proportion of obese/overweight patients will manage to keep the weight off, and the rest of the patient population tends to be divided into two groups: those who regain most of it (usually around half of the lost weight will be regained within 2 years, and 80% by follow up year 5), and those who regain more weight than they had lost. There hasn't been a way to tell preemptively which group the patient will land in at the time of beginning of lifestyle modification.

On top of this, yoyo-ing is also a phenomenon we tend to see. Obese and overweight patients who've managed to lose weight once will regain, lose again and so on. This phenomenon is associated with worse outcomes than being obese alone, so it is important to do long-horizon thinking when initiating therapy (be it lifestyle or pharmacotherapy) e.g. is the patient willing to stay on pharmacotherapy indefinitely? what about an indefinite maintenance dose if the patient succeeds with lifestyle modification alone? has the patient had lost and regained significant amount of wt prior? etc.